肿瘤防治研究2025，Vol.52Issue(9)：798-805,8.DOI:10.3971/j.issn.1000-8578.2025.25.0121
环状RNA与蛋白质泛素化修饰在癌症中的研究进展
Research Progress of Circular RNA and Protein Ubiquitination Modification in Cancer
摘要
Abstract
Circular RNAs(circRNAs)are a class of noncoding RNA molecules with a covalently enclosed circular structure and are more stable than linear RNAs.CircRNAs possess unique characteristics and biological functions,playing key roles in the occurrence and development,proliferation,metastasis,invasion,and drug resistance of various types of cancer.Protein ubiquitination modification regulates the stability and functions of proteins through the ubiquitin-proteasome system(UPS),and affecting tumor-related signal transduction pathways.Interactions between circRNAs and UPS in cancer have attracted considerable interest.They may be novel biomarkers for cancer therapy and potential targets for mitigating tumors'drug resistance.This article systematically reviews the molecular mechanism and clinical translational potential of circRNAs and protein ubiquitination modification in cancer and discusses their application prospects in diagnosis,treatment prognosis and overcoming drug resistance.关键词
circRNAs/泛素化/癌症/泛素-蛋白酶体系统Key words
CircRNAs/Ubiquitination/Cancer/Ubiquitin-proteasome system分类
医药卫生引用本文复制引用
黄秦天,官成浓..环状RNA与蛋白质泛素化修饰在癌症中的研究进展[J].肿瘤防治研究,2025,52(9):798-805,8.基金项目
Guangdong Basic and Applied Basic Research Foundation Provincial-Municipal Joint Fund(No.2023A1515140082) （No.2023A1515140082）
The Fifth Batch of High-level Talent Research Funding Program of the First Affiliated Hospital of Guangdong Medical University in Dongguan(No.GCC2024006) （No.GCC2024006）
"Climbing Peak 100"Joint Exc-ellence Program of the First Affiliated Hospital of Guangdong Medical University in Dongguan(No.PF100-1-07) 广东省基础与应用基础研究基金省市联合基金(2023A1515140082) （No.PF100-1-07）
广东医科大学附属东莞第一医院第五批高层次人才科研资助计划(GCC2024006) （GCC2024006）
广东医科大学附属东莞第一医院"攀峰100"联合培优计划(PF100-1-07) （PF100-1-07）
