浙江大学学报（医学版）2025，Vol.54Issue(4)：455-468,14.DOI:10.3724/zdxbyxb-2025-0087
水凝胶药物递送系统在心肌梗死治疗中的研究进展
Advances in hydrogel drug delivery systems for myocardial infarction treatment
摘要
Abstract
Myocardial infarction is a cardiovascular disease with high morbidity and mortality rates.Hydrogel biomaterials mimicking the extracellular matrix have recently been shown to demonstrate excellent biocompatibility,low immunogenicity,favorable biodegradability,and multifunctionality,showcasing significant potential for treatment of myocardial infarction.Hydrogels can provide mechanical support to the damaged myo-cardium,alleviating pathological remodeling.Moreover,their porous structure makes them ideal carriers for localized and sustained drug delivery.Hydrogels derived from various matrices-including polysaccharides,polypeptides,proteins,decellularized extracellular matrix,and synthetic polymers—exhibit distinct properties in terms of biocompatibility,mechanical performance,and drug delivery capacity.These hydrogels support tissue regeneration and enable targeted release of diverse therapeutics,meeting the various therapeutic demands for myocardial repair.In the infarcted myocardial microenvironment,endogenous signals such as low pH,specific enzyme expression,and elevated levels of reactive oxygen species can trigger responsive drug release from hydrogels,while external physical stimuli-such as ultrasound,light,and magnetic fields-can also be employed to precisely control the release process,thereby enhancing therapeutic efficacy and reducing systemic side effects.This review summarizes recent advances in hydrogel-based drug delivery systems for treatment of myocardial infarction,focusing particularly on the characteristics and advantages of different hydrogel materials for myocardial repair.Furthermore,the responsive drug release behavior of hydrogels is analyzed in the context of the cardiac injury microenvironment,providing a reference for future research.关键词
心肌梗死/水凝胶/药物递送系统/刺激响应材料/综述Key words
Myocardial infarction/Hydrogel/Drug delivery system/Stimuli-responsive materials/Review分类
医药卫生引用本文复制引用
杨佳,周正,谢夏虹,叶明舟..水凝胶药物递送系统在心肌梗死治疗中的研究进展[J].浙江大学学报（医学版）,2025,54(4):455-468,14.基金项目
国家自然科学基金(82272140) （82272140）
苏州市重大创新团队(ZXT2022007) （ZXT2022007）
江苏省前沿引领技术基础研究重大项目(BK20232046) （BK20232046）
苏州市类器官与精准治疗重点实验室(SZS2023006) This work was supported by National Natural Science Foundation of China(82272140),Suzhou Major Innovation Team Program(ZXT2022007),Jiangsu Provincial Basic Research Program of Frontier Leading Technologies(BK20232046),and Suzhou Key Laboratory of Organoids and Precision Medicine(SZS2023006) （SZS2023006）
