浙江大学学报（医学版）2025，Vol.54Issue(4)：469-478,10.DOI:10.3724/zdxbyxb-2024-0651
不同尺寸生物材料应用于实体肿瘤过继细胞免疫疗法研究进展
Biomaterials of different sizes for enhanced adoptive cell transfer therapy in solid tumors
摘要
Abstract
Adoptive cell transfer(ACT)shows significant efficacy against hema-tological malignancies but is limited in solid tumors due to poor homing,immunosuppre-ssion,and potential toxicity.Biomaterials spanning from nano-to macroscales-including nanoparticles,microspheres/micropatches,and hydrogels—offer unique advantages for ex vivo cell engineering,in vivo delivery,and modulation of the tumor microenvironment.Specifically,nanoparticles enable gene delivery,artificial antigen-presenting cell engi-neering,and immune microenvironment remodeling.Microspheres/micropatches improve immune cell expansion,targeted activation,and localized retention.Hydrogels enhance ACT via in situ genetic engineering,3D culture support,and cytokine co-delivery.This review summarizes advances in biomaterial-enhanced ACT,highlighting their potential to improve delivery efficiency,amplify antitumor responses,and reduce toxicity.These insights may accelerate the clinical translation of ACT for solid tumors.关键词
过继细胞输注/嵌合抗原受体T细胞治疗/生物材料/药物递送/免疫细胞/肿瘤微环境/综述Key words
Adoptive cell transfer/Chimeric antigen receptor T cell therapy/Biomaterials/Drug delivery/Immune cells/Tumor microenvironment/Review分类
医药卫生引用本文复制引用
陈佳新,刘睿,汤迎琦,钱程根..不同尺寸生物材料应用于实体肿瘤过继细胞免疫疗法研究进展[J].浙江大学学报（医学版）,2025,54(4):469-478,10.基金项目
国家自然科学基金(82072069) （82072069）
江苏省优秀青年基金(BK20220153) This work was supported by National Natural Science Foundation of China(82072069)and Jiangsu Provincial Outstanding Youth Fund(BK20220153) （BK20220153）
