浙江中医药大学学报2025，Vol.49Issue(8)：983-989,7.DOI:10.16466/j.issn1005-5509.2025.08.004
从三焦-膜原-玄府体系论治原发性干燥综合征肾损害
Exploring the Pathogenesis and Treatment of Renal Involvement in Primary Sjögren's Syndrome Based on the"Sanjiao-Moyuan-Xuanfu"System
摘要
Abstract
[Objective]To explore the traditional Chinese medicine(TCM)pathogenesis and treatment strategies for renal involvement in primary Sjögren's syndrome(pSS)by using the"Sanjiao-Moyuan-Xuanfu"system.[Methods]By analyzing the structural and functional connotations of Sanjiao(triple energizer),Moyuan(membranous source)and Xuanfu(subtle pores),combined with the renal pathological mechanisms of renal involvement in pSS,it summarized the diagnostic and therapeutic approach for pSS renal damage based on the Sanjiao-Moyuan-Xuanfu system.A validated case was included for illustration.[Results]The Sanjiao-Moyuan-Xuanfu system is characterized by membranous structures taken as its physical basis and the circulation of Qi and fluids as its functional core.The kidney can be analogized as a microcosmic Sanjiao-Moyuan-Xuanfu system.The study proposes that spleen-kidney deficiency and impaired Qi transformation in Sanjiao constitute the core pathogenesis of the disease.Macroscopically,it manifests as endogenous dampness,heat,phlegm and blood stasis;microscopically,it is characterized by stagnation in Moyuan and dysfunction of Xuanfu,which serve as critical turning points in the disruption of kidney Qi movement and the degeneration of renal Xuanfu.The treatment strategy emphasizes harmonizing dryness and dampness,regulating the spleen and kidney to restore Sanjiao Qi dynamics,while simultaneously dispersing latent pathogens in renal Moyuan and promoting blood circulation to resolve stasis and unblock Xuanfu.The attached case involved a complication of dryness-Bi syndrome with blood stasis and water retention,treated with blood-activating and water-draining methods,spleen-strengthening and dampness-resolving therapy,as well as liver-kidney nourishing and heat-clearing approaches,yielding favorable outcomes.[Conclusion]The Sanjiao-Moyuan-Xuanfu system is involved in the distribution of Qi and body fluids.Under pathological conditions,dysfunction of this system provides a novel perspective for elucidating the pathological features of renal involvement in pSS,offering theoretical and methodological insights for its clinical diagnosis and treatment.关键词
干燥综合征肾损害/三焦-膜原-玄府体系/三焦气化/水液代谢/肾脏微观病理/脾肾同治/透散伏邪/活血解玄Key words
renal involvement in Sjögren's syndrome/Sanjiao-Moyuan-Xuanfu system/Sanjiao Qi transformation/body fluid metabolism/microscopic renal pathology/spleen-kidney dual regulation/dissipating latent pathogen/blood-activating and Xuanfu unblocking分类
医药卫生引用本文复制引用
常悦,周静威..从三焦-膜原-玄府体系论治原发性干燥综合征肾损害[J].浙江中医药大学学报,2025,49(8):983-989,7.基金项目
国家自然科学基金面上项目(81874401) （81874401）
中央高校基本科研业务费专项资金资助项目(2020-JYB-ZDGG-118)National Natural Science Foundation General Project(81874401) （2020-JYB-ZDGG-118）
Specialized Fund for Basic Scientific Research Business Expenses of Central Universities(2020-JYB-ZDGG-118) （2020-JYB-ZDGG-118）
