中国中药杂志2025，Vol.50Issue(14)：3868-3877,10.DOI:10.19540/j.cnki.cjcmm.20250425.201
植物来源外泌体样纳米囊泡在肠道疾病中的应用特点研究进展
Research progress in application characteristics of plant-derived exosome-like nanovesicles in intestinal diseases
摘要
Abstract
Inflammatory bowel disease is a chronic,idiopathic,and recurrent gastrointestinal disorder with an unclear etiology and uncertain pathogenesis.Traditional treatment strategies rely on frequent administration of high doses of medication to reduce inflammation,whereas these approaches have limitations and may induce potential complications.Therefore,finding more effective and safe therapeutic drugs and methods is particularly important.Plant-derived exosome-like nanovesicles(PDELNs)are nano-sized vesicles with a lipid bilayer structure that are secreted by plant cells.The bioactive molecules contained within,such as lipids,proteins,and nucleic acids,can serve as information carriers,playing a role in the transmission of information and substances between cells and across species.PDELNs can carry and transfer their own bioactive substances or act as carriers for delivering other active components or drugs.Due to the high biocompatibility,low toxicity,and significant bioactivity,PDELNs have garnered widespread attention.Compared with other exosomes,PDELNs are not destroyed in the gastrointestinal tract when taken orally and can reach the intestines.This unique property makes PDELNs a promising oral nanodrug for treating intestinal diseases,showing great potential in this area.This article reviews recent research literature on PDELNs regarding the physicochemical characteristics,extraction and purification methods,functions,application characteristics and mechanisms in the treatment of intestinal diseases,and use as a carrier for treating intestinal diseases,aiming to provide a reference for the use of PDELNs in the treatment of intestinal diseases.关键词
植物外泌体/植物来源外泌体样纳米囊泡/肠道疾病/炎症性肠病/提取纯化/纳米载体Key words
plant exosomes/plant-derived exosome-like nanovesicles/intestinal diseases/inflammatory bowel disease/extraction and purification/nanocarriers引用本文复制引用
左圆,张金英,许圣东,田硕,苗明三..植物来源外泌体样纳米囊泡在肠道疾病中的应用特点研究进展[J].中国中药杂志,2025,50(14):3868-3877,10.基金项目
国家自然科学基金项目(82274119) （82274119）
岐黄学者项目(国中医药人教函2022-6) （国中医药人教函2022-6）
河南省重点科技计划项目(232301420019) （232301420019）
河南省杰出外国专家工作室项目(38103029-2024) （38103029-2024）
河南省中医药科学研究专项(2024ZYZD15) （2024ZYZD15）
河南省科技研发计划联合基金项目(优势学科培育类242301420106) （优势学科培育类242301420106）
