浙江大学学报（医学版）2025，Vol.54Issue(4)：479-488,10.DOI:10.3724/zdxbyxb-2025-0093
中性粒细胞药物递送系统研究进展
Advancement in neutrophil-based drug delivery systems
摘要
Abstract
Neutrophils,as the most abundant immune cells in the human body,possess the inherent ability to rapidly migrate to sites of inflammation and infection.Novel drug delivery systems leveraging neutrophils capitalize on their natural targeting and phagocytic capabilities to achieve precise drug delivery.Efficient drug loading into neutrophils within neutrophil-based delivery systems can be achieved through physical adsorption,chemical conjugation,and phagocytosis.Design strategies emphasize carrier selection and targeting ligand design to enhance delivery precision.Compared to traditional drug delivery systems,neutrophil-based systems offer significant advantages,including excellent biocompatibility and strong tissue penetration.These properties can significantly improve drug bioavailability and reduce adverse reactions associated with non-target tissue accumulation.However,these systems also face several challenges that require resolution,such as difficulties in cell collection and preservation,the need for stability optimization,challenges in large-scale production,and a lengthy clinical translation cycle.In disease treatment applications,neutrophil-based drug delivery systems enable precise delivery of anti-cancer drugs to tumor sites,potentially disrupting immunosuppression of the tumor microenvironment and enhancing therapeutic efficacy.For brain diseases,their unique ability to cross the blood-brain barrier facilitates effective drug delivery.In chronic inflammatory diseases,neutrophil-based systems can precisely deliver anti-inflammatory agents to mitigate inflammation.Performance enhancements for neutrophil-based systems can be achieved by the development of novel nanomaterials and optimization of targeting ligand affinity,thereby improving the accuracy and efficiency of drug delivery.This review comprehensively explores the design strategies,advantages,challenges,and future directions of neutrophil-based drug delivery systems.It summarizes research progress in disease treatment applica-tions,aiming to offer key insights for the development of novel drug delivery systems and advance precision medicine and targeted therapy.关键词
药物递送系统/中性粒细胞/精准医疗/靶向治疗/综述Key words
Drug delivery system/Neutrophils/Precision medicine/Targeted therapy/Review分类
医药卫生引用本文复制引用
周子晗,唐龙光..中性粒细胞药物递送系统研究进展[J].浙江大学学报（医学版）,2025,54(4):479-488,10.基金项目
国家自然科学基金(82270113,32201127) This work was supported by National Natural Science Foundation of China(82270113,32201127) （82270113,32201127）
