中兽医医药杂志2025，Vol.44Issue(5)：41-48,8.DOI:10.13823/j.cnki.jtcvm.2025.058
药物调控巨噬细胞极化防治动脉粥样硬化研究进展
Review on the regulation of macrophage polarization by drugs for the prevention and treatment of atherosclerosis
摘要
Abstract
Atherosclerosis is a cardiovascular disease characterized by chronic inflammation and abnormal lipid metabolism.Its occurrence and development are closely related to the polarization state of macrophages in the vascular intima.Macrophages could be polarized into pro-inflammatory M1-type macrophages or anti-inflammatory M2-type macrophages in different microenvironments of atherosclerotic plaques,thereby affecting the formation,progression and stability of atherosclerotic plaques.Drugs that regulate the polarization state of macrophages,reduce inflammatory responses and promote plaque stability have become a research hotspot in the prevention and treatment of atherosclerosis.In recent years,the research on drugs regulating macrophage polarization has shown a diversified trend.They exert the effects of improving macrophage function and regulating local inflammatory responses through different mechanisms,thereby having a positive impact on the prevention and treatment of atherosclerosis.However,there are still problems such as insufficient drug specificity,unclear mechanisms of action and inconsistent clinical application effects.This article summarizes the mechanisms of action and clinical application prospects of different drugs in regulating macrophage polarization for the prevention and treatment of AS.In the future,targeted delivery systems can be developed as a priority to enhance the selectivity and delivery efficiency of drugs,reduce the systemic side effects of drugs,and provide theoretical basis and new ideas for the precise prevention and treatment of AS.关键词
动脉粥样硬化/巨噬细胞极化/M1/M2型巨噬细胞/炎症反应/药物靶点/调控机制Key words
atherosclerosis/macrophage polarization/M1/M2 macrophages/inflammatory response/drug target/regulatory mechanism分类
农业科技引用本文复制引用
秦哲,曹宇倩,李剑勇..药物调控巨噬细胞极化防治动脉粥样硬化研究进展[J].中兽医医药杂志,2025,44(5):41-48,8.基金项目
兰州市青年科技人才创新项目(2023-QN-74) （2023-QN-74）
甘肃省自然科学基金项目(24TRRA023) （24TRRA023）
