肿瘤防治研究2025，Vol.52Issue(9)：731-735,5.DOI:10.3971/j.issn.1000-8578.2025.25.0396
TIM3相关通路在骨髓增生异常综合征免疫发病机制及靶向治疗中的作用
Role of TIM3 Pathway in Immune Pathogenesis and Targeted Therapy of Myelody-splastic Syndrome
摘要
Abstract
Myelodysplastic syndrome(MDS),a myeloid tumor derived from the malignant clones of hematopoietic stem cells,has an annually increasing incidence.The contemporary res-earch direction has shifted to analyzing the synergistic effect of immune surveillance collapse and abnormal bone marrow mic-roenvironment in the pathological process of MDS.Against this backdrop,the immune checkpoint molecule TIM3 has eme-rged as a key target because of its persistently high expression on the surface of important immune cells such as T and NK cells.The abnormal activation of the TIM3 pathway is the mec-hanism by which solid tumors and hematological malignancies achieve immune escape and is a key hub in the formation of immune exhaustion phenotypes.This work integrates the orig-inal discoveries of our team with the latest international prog-ress,systematically demonstrating the bidirectional regulatory network of TIM3 between the malignant clone proliferation of MDS and the immunosuppressive microenvironment.Integr-ating the evidence from emerging clinical trials allows us to consider the clinical significance of TIM3-targeted blocking for MDS,providing a transformative path to overcome the resistance of traditional treatments and marking a new chapter in the active immune reconstitution of MDS treatment.关键词
T细胞免疫球蛋白黏蛋白3/骨髓增生异常综合征/信号通路/免疫检查点/免疫逃逸/靶向治疗Key words
TIM3/Myelodysplastic syndrome/Signaling path-way/Immune checkpoints/Immune escape/Targeted therapy分类
医药卫生引用本文复制引用
郭欣雨,余顺杰,陶景莲,王英帅,任晓彤,刘召云,付蓉,邵宗鸿,李丽娟..TIM3相关通路在骨髓增生异常综合征免疫发病机制及靶向治疗中的作用[J].肿瘤防治研究,2025,52(9):731-735,5.基金项目
天津市卫生健康科技项目医学重点学科(TJWJ2024XK003) Medical Key Discipline of Tianjin Health Science and Technology Project(No.TJWJ2024XK003) （TJWJ2024XK003）
