肿瘤防治研究2025，Vol.52Issue(9)：736-740,5.DOI:10.3971/j.issn.1000-8578.2025.25.0048
α-SMA和梭形细胞Vimentin的表达及其与黏液纤维肉瘤患者预后的关系
Expression Levels of α-SMA and Vimentin in Spindle Cells and Their Relationship with Prognosis of Patients with Myxofibrosarcoma
吴国慧 1张燕2
作者信息
- 1. 100048 北京,中国人民解放军总医院第四医学中心病理科
- 2. 390-8621 长野县松本,信州大学医学部
- 折叠
摘要
Abstract
Objective To analyze the expression levels of a-smooth muscle actin(α-SMA)and Vimentin in spindle cells and their relationship with the prognosis of patients with myxofibrosarcoma(MFS).Methods The imaging,clinical,and pathological data of 61 patients with MFS were collected.All patients were confirmed by surgical and postoperative pathological examination.Immunohistochemical methods were used to determine the positive proportion of α-SMA and Vimentin.The correlation between the expression levels of α-SMA and Vimentin in spindle cells and prognosis was analyzed.Results The positive rates of α-SMA and Vimentin expression in MFS tissues were 68.85%and 60.66%,respectively.The expression of Vimentin was not significantly correlated with 3-year OS and DFS(P=0.351,P=0.284).The expression of α-SMA was significantly correlated with OS and DFS(P=0.030,P=0.017),and patients with high expression of α-SMA have shorter OS and DFS.Conclusion Determining α-SMA level can help evaluate the prognosis of patients with MFS and guide clinical treatment.关键词
α-SMA/梭形细胞Vimentin/黏液纤维肉瘤Key words
α-SMA/Spindle cell Vimentin/Myxofibrosarcoma分类
医药卫生引用本文复制引用
吴国慧,张燕..α-SMA和梭形细胞Vimentin的表达及其与黏液纤维肉瘤患者预后的关系[J].肿瘤防治研究,2025,52(9):736-740,5.
