中华中医药学刊2025，Vol.43Issue(9)：202-205,4.DOI:10.13193/j.issn.1673-7717.2025.09.037
扶脾益肾方结合手工根面平整术治疗重度慢性牙周炎(脾肾阳虚型)临床效果及对炎性因子影响观察
Clinical Effect of Fupi Yishen Recipe(扶脾益肾方)Combined with Manual Root Surface Leveling in Treatment of Severe Chronic Periodontitis(Spleen-Kidney Yang Deficiency Type)and Its Influence on Inflammatory Factors in Patients
摘要
Abstract
Objective To observe the clinical effect of Fupi Yishen Recipe(扶脾益肾方)combined with manual root surface leveling in the treatment of severe chronic periodontitis(spleen-kidney Yang deficiency type)and its effect on inflammatory fac-tors.Methods A total of 102 patients with severe chronic periodontitis(spleen-kidney-yang deficiency type)admitted from January 2020 to January 2024 were included in the group study.The patients were divided into the simple operation group and the combined Chinese medicine group by random number table method,with 51 cases in each group.All patients in the simple operation group received manual root planarization treatment.Those in the combined Chinese medicine group were treated with manual root surface leveling and Fupi Yishen Recipe.During the treatment and study,1 patient in the simple operation group fell off,and 2 patients in the combined Chinese medicine group fell off.The clinical efficacy,integral changes of TCM symptoms(main symptoms,secondary symptoms and tongue and pulse)before and after treatment,the changes of periodontal index and concentration of inflammatory factors in gingival crevicular fluid,the changes of masticatory function(bite force and masticatory ef-ficiency)and the adverse reactions of treatment of two groups were observed.Results The total effective rate of the combined Chi-nese medicine group was higher than that of the operation group(P＜0.05).Before treatment,the scores of TCM symptoms(main symptoms,secondary symptoms and tongue and pulse),periodontal indices such as gingival bleeding index(BI),plaque index(PLI)and loss of attachment(AL),depth of periodontal probe(PD),concentration of inflammatory factors such as tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)in gingival crevicular fluid,and chewing function(biting force)of patients in both groups had no significance(all P＞0.05).After treatment,the above indexes were all improved and those in the com-bined Chinese medicine group were better than those in the simple operation group(all P＜0.05).No serious adverse reactions were observed in the combined Chinese medicine group and the simple operation group(P＞0.05).Conclusion Fupi Yishen Recipe combined with manual root surface leveling has significant clinical effect in the treatment of severe chronic periodontitis(spleen-kidney Yang deficiency type),which can effectively reduce the concentration of inflammatory factors in gingival crevic-ular fluid,improve the clinical symptoms,periodontal index and masticatory function of patients and promote the recovery of pa-tients.The treatment is relatively safe and reliable.关键词
重度慢性牙周炎/脾肾阳虚型/扶脾益肾方/手工根面平整术/疗效/龈沟液内炎症因子浓度/牙周指数Key words
severe chronic periodontitis/spleen-kidney Yang deficiency type/Fupi Yishen Recipe(扶脾益肾方)/manual root surface leveling/curative effect/concentration of inflammatory factors in gingival crevicular fluid/periodontal index分类
医药卫生引用本文复制引用
蒋文卉,曹峥,李寅..扶脾益肾方结合手工根面平整术治疗重度慢性牙周炎(脾肾阳虚型)临床效果及对炎性因子影响观察[J].中华中医药学刊,2025,43(9):202-205,4.基金项目
浙江省中医药科技计划项目(2024ZL1025) （2024ZL1025）
