Reversal of amino acid metabolism patterns between circulating blood and tumors as a new biomarker for the Zhengxu Xieshi syndrome in patients with esophageal squamous cell carcinoma
WANG Siliang ZHENG Miaomiao YANG Xi PAN Jun XU Hanchen DONG Changsheng CHEN Wenlian MA Yushui LIU Lei WANG Pei WU Jia JIN Xing JIN Qiang WANG Congcong QIN Chentai
Reversal of amino acid metabolism patterns between circulating blood and tumors as a new biomarker for the Zhengxu Xieshi syndrome in patients with esophageal squamous cell carcinoma
Reversal of amino acid metabolism patterns between circulating blood and tumors as a new biomarker for the Zhengxu Xieshi syndrome in patients with esophageal squamous cell carcinoma
摘要
关键词
esophageal squamous cell carcinoma/metabolic reprogramming/amino acid metabolism/Zhengxu Xieshi syndrome/vital Qi/evil QiKey words
esophageal squamous cell carcinoma/metabolic reprogramming/amino acid metabolism/Zhengxu Xieshi syndrome/vital Qi/evil Qi引用本文复制引用
WANG Siliang,ZHENG Miaomiao,YANG Xi,PAN Jun,XU Hanchen,DONG Changsheng,CHEN Wenlian,MA Yushui,LIU Lei,WANG Pei,WU Jia,JIN Xing,JIN Qiang,WANG Congcong,QIN Chentai..Reversal of amino acid metabolism patterns between circulating blood and tumors as a new biomarker for the Zhengxu Xieshi syndrome in patients with esophageal squamous cell carcinoma[J].中医杂志（英文版）,2025,45(4):896-908,13.基金项目
Supported by Natural Science Foundation-funded Project:Establishment of Syndrome-Disease Warning System and Investigation of the Clinical Features and Evolution Patterns of Traditional Chinese Medicine Syndromes in Esophageal Cancer under Modern Medical Diagnosis and Treatment(2023YFC3503200,2023YFC3503201) （2023YFC3503200,2023YFC3503201）
Biological Basis of the Pathogenesis of Cancer Toxin in Traditional Chinese Medicine(2022YFC3500200,2022YFC3500202).Natural Science Foundation-funded Project:Mechanistic Study of the Nucleolar Methyltransferase Fibrillarin to Promote Neoplastic Growth of Esophageal Squamous Cell Carcinoma via Activating Nucleoside Synthesis(No.32170778) （2022YFC3500200,2022YFC3500202）
Mechanistic Study of Renal Cancer Neoplastic Growth Driven by Glucose Transporter 5-Mediated Fructose Metabolism Reprogramming(No.31970708) （No.31970708）
Mechanistic Study of Methionine Cycle Modulating the Growth of Esophageal Squamous Cell Carcinoma through"DNA Methylation-DNA Stability-p53/p21-cell Cycle"Pathway(No.82002953) （No.82002953）
the Antitumor Mechanism of Oleanolic Acid via Autophagy by Regulating Adenosine Monophosphate-Activated Protein Kinase-Mammalian Target of Rapamycin-Unc51 Like Kinase 1 Pathway and Inhibiting Purine Salvage Pathway(No.82004177) （No.82004177）
USP14 Cooperates with Ubiquitin C-Terminal Hydrolase L5 to Regulate Constitutive Photomorphogenic 9 Signalosome-mediated Programmed Death-Ligand 1 Deubiquitination and Promote Immune Evasion in Hepatocellular Carcinoma.(No.81972214).National Scientific and Technological Major Special Project of China:Shuang Huang Sheng Bai Oral Liquid:Efficacy and Safety Evaluation of Traditional Chinese Medicine Compound Based on Systems Biology Approaches(2019ZX09201004-002-013).A special clinical research initiative for the health business sponsored by the Shanghai Municipal Health Commission(No.202040155),Shanghai Municipal Science and Technology Commissions Special Biomedical Technology Support Plan(No.20S31904100),Shanghai"Science and Technology Innovation Action Plan"Medical Innovation Research Project--Shanghai Clinical Research Center of Traditional Chinese Medicine Oncology(21MC1930500),Shanghai 13th Five-Year Plan Key Specialty of Traditional Chinese Medicine Oncology(shslczdzk03701),Tracking Programme for Eastern Scholar at Shanghai Institutions of Higher Learning,Shanghai High-level Talent Leadership Programme of Traditional Chinese Medicine[ZY(2021-2023)-0403],and Scientific Research Project of Industry Development Center of Shanghai University of Traditional Chinese Medicine(602076D) （No.81972214）
