中华中医药学刊2025，Vol.43Issue(9)：219-225,7.DOI:10.13193/j.issn.1673-7717.2025.09.041
中药及有效成分调控NF-κB信号通路治疗痛风的研究进展
Research Progress of Traditional Chinese Medicine and Its Active Ingredients in Regulating NF-κB Signaling Pathway in Treatment of Gout
摘要
Abstract
Gout is a recurrent metabolic disease with abnormal purine content and/or uric acid concentration in the body.The common clinical manifestation of gout is gouty arthritis(GA),which is a series of inflammatory reactions(heterologous disea-ses)caused by the accumulation of monosodium urate crystals(MSU)in surrounding tissues such as joint capsules,cartilage,sy-novium,etc.Nuclear factor-κB(NF-κB)signaling pathway,as an important mechanism of inflammation,is highly expressed in gout.Activated upstream receptors induce cells to produce tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),inter-leukin-1β(IL-1β)and other pro-inflammatory factors through NF-κB signaling pathway.This leads to inflammation.Tra-ditional Chinese medicine(TCM)has a long history in the prevention and treatment of gout,with definite clinical efficacy and few side effects,and has the characteristics and advantages of multi-targets and extensive sources.According to the research at home and abroad,it is found that traditional Chinese medicine and its active ingredients could reduce the production of inflammatory factors,improve the inflammatory response and alleviate the attack of gout by regulating the NF-κB signaling pathway.In order to supplement the scientific nature of clinical medication and explore its pharmacological mechanism,this article reviewed the lat-est research results and mechanism of traditional Chinese medicine and active ingredients in the treatment of gout by regulating NF-κB signaling pathway by referring to relevant domestic and foreign literature,in order to provide scientific ideas for the clini-cal application of traditional Chinese medicine and provide reference for promoting the development of new drugs.关键词
痛风/中药单体/中药有效成分/NF-κB信号通路/研究进展Key words
gout/traditional Chinese medicine monomer/active ingredients of traditional Chinese medicine/NF-κB signa-ling pathway/research progress分类
医药卫生引用本文复制引用
马宏武,谢兴文,李宁,李鼎鹏,赵永利,黄委委,程渊,袁可馨..中药及有效成分调控NF-κB信号通路治疗痛风的研究进展[J].中华中医药学刊,2025,43(9):219-225,7.基金项目
甘肃省科技重大专项计划项目(22ZD6FA020) （22ZD6FA020）
甘肃省中医药管理局重点项目(GZKZ-2020-6) （GZKZ-2020-6）
甘肃省科技重大专项-企业创新联合体项目(22ZD6FA021) （22ZD6FA021）
甘肃省拔尖人才(科学技术领域)培养扶持资金项目(省委人才小组函[2021]2号) （科学技术领域）
2023甘肃省高校产业支撑计划项目(2023CYZC-57) （2023CYZC-57）
