中医药信息2025，Vol.42Issue(9)：58-63,6.DOI:10.19656/j.cnki.1002-2406.20250910
基于"瘀毒"理论与线粒体质量控制探讨缺血性心力衰竭病因病机
Exploring the Etiology and Pathogenesis of Ischemic Heart Failure Based on"Stasis-Toxin"Theory and Mitochondrial Quality Control
摘要
Abstract
Ischemic heart failure is a clinical syndrome caused by insufficient coronary blood supply,leading to myocardial ischemia,hypoxic injury,and subsequent cardiac pump dysfunction.Traditional Chinese Medicine(TCM)theory posits that endogenous"stasis-toxin"obstructs qi and blood circulation,depriving the heart of nourishment,resulting in myocardial hypoxia,abnormal energy metabolism,and myocardial injury,which accompany the onset and progression of ischemic heart failure.Mitochondria,as the energy factories of cells,rely on their quality control mechanisms(e.g.,fusion and fission,autophagy,oxidative stress)to maintain cardiomyocyte function.By reviewing the correlation between the TCM"stasis-toxin"theory and mitochondrial quality control in ischemic heart failure,and combining the pathophysiological characteristics of ischemic heart failure,this study explores the general patterns and scientific connotation of"stasis-toxin"syndrome evolution at different stages.It proposes that"stasis-toxin"affects mitochondrial function and that the therapeutic approach of"activating blood circulation and detoxifying"may regulate mitochondrial quality control,providing new research directions and treatment strategies for the prevention and management of ischemic heart failure.关键词
缺血性心力衰竭/线粒体质量控制/瘀毒理论/活血解毒Key words
Ischemic heart failure/Mitochondrial quality control/Stasis-toxin theory/Activating blood circulation and detoxifying引用本文复制引用
李思耐,刘梦婷,邢文龙,尚菊菊,刘卫红,周明学..基于"瘀毒"理论与线粒体质量控制探讨缺血性心力衰竭病因病机[J].中医药信息,2025,42(9):58-63,6.基金项目
国家自然科学基金面上项目(82205098,82174106) （82205098,82174106）
