阿尔茨海默病及相关病2025，Vol.8Issue(5)：291-296,303,7.DOI:10.3969/j.issn.2096-5516.2025.05.001
时间动态视角下整合阿尔茨海默病连续疾病谱中的血液和神经影像学生物标志物
Integrating blood and neuroimaging biomarkers across the Alzheimer's disease continuum:A temporal dynamics perspective
摘要
Abstract
Alzheimer's disease(AD)is a neurodegenerative disorder characterized by a long preclinical phase and a cascade of pathological events.With recent advances in blood and imaging biomarkers,the dynamic tracking of AD progression has become increasingly feasible.However,most studies have focused on single-modality markers,with limited integration across biological systems and time scales.This review adopts a time-dynamic perspective to summarize the longitudinal evolution of key blood biomarkers(e.g.,Aβ42/40 ratio,p-tau217,NfL,GFAP)and imaging markers(e.g.,Aβ-PET,Tau-PET,MRI)across the AD continuum.We compare the timing of initial abnormalities,progression patterns,and correlations with cognitive decline.Furthermore,we highlight integrative modeling approaches,including event-based models,and deep learning frameworks,which enable multi-modal risk prediction and individualized disease staging.The clinical potential of such integration in early screening,disease trajectory forecasting,and therapeutic decision-making is discussed,along with current limitations and future directions.This review provides a framework for developing dynamic,biology-driven precision diagnostic strategies in AD.关键词
阿尔茨海默病/血液标志物/PET/MRI/多模态整合Key words
Alzheimer's disease/Blood biomarkers/PET/MRI/Multimodal integration分类
医药卫生引用本文复制引用
杨婕懿,徐群..时间动态视角下整合阿尔茨海默病连续疾病谱中的血液和神经影像学生物标志物[J].阿尔茨海默病及相关病,2025,8(5):291-296,303,7.基金项目
上海市科学技术委员会(23ZR1439200) （23ZR1439200）
