北京中医药2025，Vol.44Issue(7)：839-842,4.DOI:10.16025/j.1674-1307.2025.07.005
通阳活血颗粒治疗病态窦房结综合征阳虚血瘀证的临床疗效观察
Clinical observation on the therapeutic effect of Tongyang Huoxue Granules in the treatment of sick sinus syndrome with yang deficiency and blood stasis syndrome
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of Tongyang Huoxue Granules in the treatment of sick sinus syndrome(SSS).Methods A total of 80 patients with yang deficiency and blood stasis type SSS admitted to Guang'anmen Hospital,China Academy of Chinese Medical Sciences from December 2018 to September 2020 were enrolled and randomly assigned to an observation group and a control group using simple block randomization,with 40 patients in each group.The observation group received Tongyang Huoxue Granules(12 g/time,2 times/day)orally,while the control group received theophylline sustained-release tablets(0.1 g/time,2 times/day)orally.Both groups were treated for 4 weeks and followed up for 6 months.Traditional Chinese medicine(TCM)syndrome scores,24-hour dynamic electrocardiogram parameters[total heart rate,average heart rate,fastest heart rate,slowest heart rate,percentage of heartbeats with adjacent sinus RR interval difference>50 ms to total sinus RR interval beats(PNN50),standard deviation of RR interval mean(SDANN),standard deviation of 24-hour sinus RR intervals(SDNN),root mean square of successive normal RR interval differences(RMSSD)],resting heart rate,safety indicators[alanine aminotransferase(ALT),aspartate aminotransferase(AST),serum creatinine(SCr),blood urea nitrogen(BUN)],and adverse events were compared before and after treatment.Results After treatment,TCM syndrome scores in the observation group decreased compared with baseline(P<0.05).In the control group,scores for palpitations,chest tightness,shortness of breath and fatigue,chest pain,cold limbs,dizziness,tinnitus,pulse,and total scores decreased compared with baseline(P<0.05).Compared with the control group after treatment,the observation group had significantly lower scores for palpitations,chest tightness,shortness of breath and fatigue,chest pain,pale complexion,dizziness and tinnitus,lip cyanosis,tongue and pulse,and total scores(P<0.05).There were no significant differences between groups in total heart rate,average heart rate,fastest heart rate,or slowest heart rate before and after treatment(P>0.05).After treatment,total heart rate,average heart rate,fastest heart rate,and slowest heart rate increased in both groups compared with baseline(P<0.05).Heart rate variability indices showed no significant differences between groups before and after treatment(P>0.05).In the observation group,PNN50 decreased compared with baseline(P<0.05),and resting heart rate increased(P<0.05).No significant changes in ALT,AST,BUN,or SCr were observed before or after treatment in either group.No adverse events occurred during treatment or follow-up.Conclusion Tongyang Huoxue Granules can increase heart rate,improve clinical symptoms,and are safe in patients with yang deficiency and blood stasis type SSS.关键词
病态窦房结综合征/通阳活血颗粒/阳虚血瘀证Key words
sick sinus syndrome/Tongyang Huoxue Granules/yang deficiency and blood stasis syndrome引用本文复制引用
关宣可,吴巧敏,常兴,刘金凤,汪艳丽,刘如秀..通阳活血颗粒治疗病态窦房结综合征阳虚血瘀证的临床疗效观察[J].北京中医药,2025,44(7):839-842,4.基金项目
首都临床特色应用研究项目(Z181100001718184) （Z181100001718184）
中国中医科学院学部委员学术传承与传播专项资助项目(CI2022E012XB) （CI2022E012XB）
北京中医药薪火传承"新3+3"工程刘志明门人(刘如秀)传承工作站(2023-SZ-G02) （刘如秀）
第六批北京市级中医药专家学术经验继承工作项目(0203001414) （0203001414）
中国中医科学院广安门医院所级课题(S2018-59940) （S2018-59940）
