材料科学与工程学报2025，Vol.43Issue(4)：531-541,588,12.DOI:10.14136/j.cnki.issn1673-2812.2025.04.004
医用硅橡胶的表面亲水改性和细胞相容性
Surface Hydrophilic Modification and Cell Compatibility of Medical Silicone Rubber
摘要
Abstract
A plasma approach was utilized in this study to treat the surface of silicone rubber and a hydrophilic polymer coating on the surface using a silane coupling agent(KH550)was generated.The hydrophilicity of the silicone rubber material was improved by altering the molecular weight and solution concentration of polyethylene glycol(PEG)and polyvinylpyrrolidone(PVP).The results indicate that both PEG and PVP solutions effectively enhance the hydrophilicity of the silicone rubber surface.The hydrophilicity of the silicone rubber was dramatically improved by using PEG and PVP synergistically,with the water contact angle decreasing from 107.9°±2.7° before modification to 57.2°±3.5° after modification.The optimal mass concentration of the PEG solution was 0.1 wt%,with an optimal molecular weight of 10000,while the optimal mass concentration of the PVP solution was also 0.1 wt%.The silicone rubber,modified with PEG and PVP in combination,shows excellent compatibility with cells.It has no discernible impact on cell morphology,cell cycle regulation,or apoptosis levels.关键词
医用硅橡胶/亲水性/生物相容性/聚乙二醇/聚乙烯吡咯烷酮Key words
Medical silicone rubber/Hydrophilicity/Bio-compatibility/Polyethylene glycol/Polyvinylpyrrolidone分类
通用工业技术引用本文复制引用
白玲,汪海风,汪翠,张伟成,王俊杰,李小雨,余沛霖,杜滨阳..医用硅橡胶的表面亲水改性和细胞相容性[J].材料科学与工程学报,2025,43(4):531-541,588,12.基金项目
浙江省科技计划项目(2022C01109) （2022C01109）
