法医学杂志2025，Vol.41Issue(3)：228-236,9.DOI:10.12116/j.issn.1004-5619.2022.521002
基于CODIS核心13个常染色体STR基因座分析不同群体中的遗传结构
Analysis of Genetic Structure among Different Populations Based on 13 Auto-somal STR Loci in CODIS Core
摘要
Abstract
Objective To investigate the genetic differences among different populations based on 13 autosomal STR loci in CODIS core.Methods Data of 13 autosomal STR loci(CSF1PO,FGA,THO1,TPOX,vWA,D3S1358,D5S818,D7S820,D8S1179,D13S317,D16S539,D18S51,D21S11)were collected from 95 populations in scientific journals between 1999 and 2021,soursed from the PubMed database,which had been published.Allele frequencies of loci were sorted out and forensic genetic parameters including gene differentiation coefficient(Gst),total heterozygosity(Ht),subpopula-tion heterozygosity(Hs)values,and Nei's DA genetic distance were calculated.Principal component analysis,phylogenetic tree,and multidimensional scale analysis were conducted to assess population ge-netic structure.Results A total of 265 alleles were detected at the 13 STR loci in these 95 popula-tions.The mean values of Gst,Ht,and Hs were 0.023 247,0.797 915 and 0.779 365.Population genetic analyses reflected significant differences among populations from Asia,Africa and Europe.In Asian populations,there was a certain degree of distinction between mainland and island populations;the Han population showed a certain degree of distinction with surrounding populations in mainland;while within the Han population,there were two distinct clusters formed by the northern Han and the south-ern Han.Conclusion The 13 autosomal STR loci in CODIS core demonstrate potential value for popu-lation identification across different groups,and may be used for the differentiation of ethnic groups,among different continental populations.关键词
法医遗传学/群体遗传学/遗传标记/常染色体STR/DNA联合索引系统Key words
forensic genetics/population genetics/genetic marker/autosomal STR/combined DNA in-dex system(CODIS)分类
医药卫生引用本文复制引用
何曦,汤真,夏明英,赵一琦,罗雨然,李士林..基于CODIS核心13个常染色体STR基因座分析不同群体中的遗传结构[J].法医学杂志,2025,41(3):228-236,9.基金项目
公安部物证鉴定中心开放课题资助项目(2015FGKFKT01) （2015FGKFKT01）
教育部科学技术研究资助项目(113022A) （113022A）
