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台式低场核磁共振技术的发展及其在禁毒领域中的应用

廖琦 刘永红 焦英 杨晓莹 杨怡华 刘翠梅 高瑞霞

法医学杂志2025，Vol.41Issue(3)：267-276,10.
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法医学杂志2025，Vol.41Issue(3)：267-276,10.DOI:10.12116/j.issn.1004-5619.2024.340402

台式低场核磁共振技术的发展及其在禁毒领域中的应用

Development of Benchtop Low-Field Nuclear Magnetic Resonance Technology and Its Application in Drug Control Field

廖琦 1刘永红 2焦英 2杨晓莹 2杨怡华 2刘翠梅 3高瑞霞4

作者信息

  • 1. 国家毒品实验室陕西分中心(陕西省公安厅毒品技术中心)陕西省毒品分析与毒情智慧监测研究重点实验室,陕西 西安 710115||西安交通大学化学学院,陕西 西安 710049
  • 2. 国家毒品实验室陕西分中心(陕西省公安厅毒品技术中心)陕西省毒品分析与毒情智慧监测研究重点实验室,陕西 西安 710115
  • 3. 公安部禁毒情报技术中心 毒品监测管控与禁毒关键技术公安部重点实验室,北京 100193
  • 4. 西安交通大学化学学院,陕西 西安 710049
  • 折叠

摘要

Abstract

At present,the drug substitutes represented by new psychoactive substances are gradually be-coming popular,leading to an increasing demand for identifying novel drugs with unknown structures in drug investigation.Nuclear magnetic resonance(NMR)spectroscopy is an important tool for ana-lyzing molecular structures.In the absence of standard substances,quantitative NMR(qNMR)can un-dertake the quantitative analysis of target substances in complex mixtures and has unique advantages in the research of new drugs and their precursor drugs.Due to the limitations of the site and mainte-nance costs,as well as relatively complex operation,high-field superconducting NMR is less com-monly applied in drug research.The desktop low-field NMR developed in recent years provides a new alternative solution.Due to the use of permanent magnets,its size is reduced,and the operation and maintenance costs are lowered.It has been widely used in various research fields.This article reviews the development of low-field NMR technology,summarizes the application of desktop low-field NMR in screening and identification of suspicious substances,rapid content determination,analysis of drug manufacturing processes and synthetic routes,and correlation traceability.It also looks forward to the prospects and development directions of this technology in drug research,aiming to provide a reference for researchers who work in analytical chemistry and drug research.

关键词

法医学/毒物分析/核磁共振/低场核磁共振/台式核磁共振波谱仪/新精神活性物质/综述

Key words

forensic medicine/toxicological analysis/nuclear magnetic resonance/low-field nuclear mag-netic resonance(LF-NMR)/benchtop NMR/new psychoactive substance/review

分类

医药卫生

引用本文复制引用

廖琦,刘永红,焦英,杨晓莹,杨怡华,刘翠梅,高瑞霞..台式低场核磁共振技术的发展及其在禁毒领域中的应用[J].法医学杂志,2025,41(3):267-276,10.

基金项目

国家重点研发计划项目(2022YFC3300902) （2022YFC3300902）

公安部科技计划项目(2021JC23) （2021JC23）

法医学杂志

OA北大核心

1004-5619

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