分子影像学杂志2025，Vol.48Issue(8)：927-932,6.DOI:10.12122/j.issn.1674-4500.2025.08.01
动态参数Ki与非小细胞肺癌预后相关:基于18F-FDG PET/CT动态显像
Correlation between the dynamic parameter Ki and prognosis in non-small cell lung cancer:based on dynamic 18F-FDG PET/CT imaging
摘要
Abstract
Objective To evaluate the differences and correlations in 18F-FDG PET/CT SUVmax and Ki among T staging,N staging,M staging and clinical staging groups in patients with non-small cell lung cancer(NSCLC).Methods A retrospective analysis was conducted on 177 patients with pathologically confirmed solitary NSCLC who underwent dynamic 18F-FDG PET/CT imaging from May 2021 to April 2024 in our hospital.Patients were categorized according to the 8th edition of the lung cancer TNM staging system as follows:T staging groups(T1/2,n=107;T3/4,n=70),N staging groups(N0/1,n=78;N2/3,n=99),M staging groups(M0,n=104;M1,n=73),and clinical staging groups(Stage Ⅰ/Ⅱ,n=55;Stage Ⅲ/Ⅳ,n=122).SUVmax was obtained from conventional static data,and Ki was obtained by applying the irreversible two-tissue compartment model using in-house Matlab software.The differences and correlations in SUVmax and Ki were analyzed among different T staging,N staging,M staging and clinical staging groups.P<0.05 was considered statistically significant.Results Significantly higher SUVmax and Ki were observed in the T3/4 group compared to the T1/2 group(P=0.001).Similarly,the N2/3 group exhibited significantly higher SUVmax and Ki values than the N0/1 group(P=0.001).Ⅲ/Ⅳ group demonstrated significantly higher SUVmax and Ki compared to Ⅰ/Ⅱ group(P=0.001).However,no statistically significant differences were found in SUVmax(P=0.056)or Ki(P=0.052)between the M1 and M0 groups.Significant positive correlations were identified between both SUVmax and Ki and T staging,N staging,as well as clinical staging(P=0.001).Conclusion The differences and correlations in SUVmax and Ki were observed among T staging,N staging and clinical staging groups,indicating potential of SUVmax and Ki in prognostic value.关键词
18F-氟脱氧葡萄糖/正电子发射体层成像/体层摄影术/动态显像/肺癌/分期Key words
18F-fluorodeoxyglucose/positron emission tomography/tomography/dynamic imaging/lung cancer/stage引用本文复制引用
周锦朋,杜芬,西尔艾力·吾门尔,马宇彤,何俊霖,梁颖..动态参数Ki与非小细胞肺癌预后相关:基于18F-FDG PET/CT动态显像[J].分子影像学杂志,2025,48(8):927-932,6.基金项目
深圳市高水平医院建设专项 （）
