分子影像学杂志2025，Vol.48Issue(8)：940-945,6.DOI:10.12122/j.issn.1674-4500.2025.08.03
18F-FDG PET/CT延迟相在肝泡型包虫病药物疗效中的评估价值
Evaluation value of 18F-FDG PET/CT delayed imaging in the drug efficacy of hepatic alveolar echinococcosis
摘要
Abstract
Objective To explore the predictive value of 18F-FDG PET/CT delayed imaging for lesion growth rate in patients with hepatic alveolar echinococcosis(HAE)who were unresponsive to drug therapy.Methods The patients with HAE who underwent dual phase(early phase+delayed phase)18F-FDG PET/CT in the Department of Nuclear Medicine,the First Affiliated Hospital of Xinjiang Medical University from January 2014 to April 2024 were retrospectively collected.A total of 32 patients who did not undergo surgery and regularly took albendazole tablets(10 mg·kg-1·d-1)orally for a long time were analysed.The maximum standard uptake value(SUVmax),tumor to background ratios(TBR),infiltration zone width(W value)and maximum diameter of HAE lesions in 32 patients were compared before and after treatment.For these 32 patients,univariate and multivariate analyses were conducted using pre-treatment factors such as age,gender,lesion location,delayed-phase 18F-FDG PET/CT SUVmax,TBR,W value,maximum diameter as independent variables,with the annual growth rate of the lesion maximum diameter as the dependent variable.Results PET showed that the HAE lesions of 32 patients before and after drug treatment all exhibit ring-shaped hypermetabolism.After treatment,the SUVmax,TBR,and maximum lesion diameter in the delayed phase of PET/CT were greater than those before treatment(P<0.01);However,no significant differences were found in the overall distribution of W values before and after treatment(P>0.05).Among these 32 patients,The SUVmax,TBR and W value of infiltration zone before treatment were correlated with the annual growth rate of maximum diameter(P<0.001).SUVmax and TBR were highly positively correlated(P＜0.001),Thus,the SUVmax value and W value before treatment were included to predict the annual growth rate of maximum diameter of HAE.Both variables included in the model significantly influenced the annual growth rate of the HAE lesion maximum diameter(P<0.05).Conclusion Pre-treatment delayed-phase PET/CT SUVmax and W values are found to be predictive of the annual growth rate of lesions in patients with ineffective HAE drug treatment.关键词
肝泡型包虫病/正电子发射计算机断层显像/氟代脱氧葡萄糖Key words
hepatic alveolar echinococcosis/positron emission tomography/fluorodeoxyglucose引用本文复制引用
阿米娜·依布拉音,秦永德,巴雅,张奇洲,李毓斌,李肖红..18F-FDG PET/CT延迟相在肝泡型包虫病药物疗效中的评估价值[J].分子影像学杂志,2025,48(8):940-945,6.基金项目
"天山英才"医药卫生高层次人才培养计划项目(TSYC202301B081) （TSYC202301B081）
