分子影像学杂志2025，Vol.48Issue(8)：952-958,7.DOI:10.12122/j.issn.1674-4500.2025.08.05
超声造影联合钆塞酸二钠增强MRI可预测肝细胞肝癌患者CD34表达及临床预后
Contrast-enhanced ultrasound combined with gadoxetic acid-enhanced MRI can predict CD34 expression and clinical prognosis in patients with hepatocellular carcinoma
摘要
Abstract
Objective To investigate the efficacy of preoperative prediction model for CD34 expression in hepatocellular carcinoma integrating contrast-enhanced ultrasound liver imaging reporting and data system(CEUS LI-RADS)and gadoxetic acid-enhanced magnetic resonance imaging(Gd-EOB-DTPA-MRI)and explore the clinical value.Methods A retrospective cohort of 111 patients of HCC who underwent radical resection at the Affiliated Tumor Hospital of Guangxi Medical University from September 2021 to August 2024.Based on the postoperative pathological and immunohistochemical results,the patients were divided into CD34-positive group(n=76)and CD34-negative group(n=35).All the patients underwent CEUS and Gd-EOB-MRI examinations before operation.Comparison of imaging characteristics between CD34-positive and CD34-negative groups,including CEUS LI-RADS categories,CEUS LI-RADS major imaging features,LI-RADS M major imaging features,non-LI-RADS imaging features and Gd-EOB-MRI features.Independent predictors of CD34 positive expression identified by multivariate logistic regression analysis and the establishment of predictive model.Results In the multivariate analysis,the imaging characteristics of LI-RADS M major imaging features(early washout),non-LI-RADS imaging features(tumor capsule,Adler blood blow grade,tumor edge morphology)and Gd-EOB-MRI imaging features(peritumor enhancement)were independent predictors of CD34.The predictive model constructed by combining the above three imaging characteristics demonstrated excellent performance,with the area under the ROC curve of 0.914,sensitivity of 0.943,and specificity of 0.789,indicating optimal predictive efficacy.Conclusion The predictive model based on CEUS LI-RADS combined with Gd-EOB-MRI demonstrates significant value in predicting CD34 expression and clinical prognosis in patients with HCC.关键词
肝细胞肝癌/超声造影/LI-RADS/钆塞酸二钠增强磁共振/CD34/预测模型Key words
hepatocellular carcinoma/contrast-enhanced ultrasound/LI-RADS/Gd-EOB-DTPA-enhanced MRI/CD34/predictive model引用本文复制引用
梁莹,吴雅菲,施洁,梁慧文,刘军杰,苏丹柯,周知展..超声造影联合钆塞酸二钠增强MRI可预测肝细胞肝癌患者CD34表达及临床预后[J].分子影像学杂志,2025,48(8):952-958,7.基金项目
广西科技基地和人才专项(桂科AD20238096) （桂科AD20238096）
