广州医药2025，Vol.56Issue(8)：1006-1020,1060,16.DOI:10.20223/j.cnki.1000-8535.2025.08.001
糖尿病肾病的重要治疗进展:从基础研究到临床应用
Important advances in diabetic nephropathy treatment:From basic research to clinical application
摘要
Abstract
Diabetic nephropathy(DN)is a form of chronic kidney disease(CKD)induced by diabetes.Diabetic nephropathy represents the leading cause of CKD and end-stage renal disease both in China and globally.The incidence of DN has been steadily increasing and its prognosis remains unfavorable.Diabetic nephropathy has become a major public health concern.Diabetic nephropathy not only significantly affects patients'quality of life but also increases the risk of cardiovascular diseases.Recent advancements in our understanding of the pathogenesis of DN have facilitated significant progress in treatment options over the past decade.These developments include the introduction of novel pharmacological agents,the implementation of lifestyle modifications,and the exploration of various emerging therapeutic approaches.This review aims to systematically expound the significant therapeutic advancements in the field of DN in recent years,evaluate the efficacy and applicability of these advancements in clinical practice,and explore potential future research directions,thereby providing valuable insights and guidance for clinical practice.关键词
糖尿病肾病/SGLT-2抑制剂/GLP-1受体激动剂/DPP-4抑制剂/盐皮质激素受体拮抗剂Key words
diabetic nephropathy/SGLT-2 inhibitors/GLP-1 receptor agonists/DPP-4 inhibitors/mineralocorticoid receptor antagonists引用本文复制引用
范李云飞,何凤..糖尿病肾病的重要治疗进展:从基础研究到临床应用[J].广州医药,2025,56(8):1006-1020,1060,16.基金项目
国家自然科学基金(82070752,82470748) （82070752,82470748）
广东省自然科学基金杰出青年基金项目(2022B1515020106) （2022B1515020106）
广东省科技计划项目(202201020273) （202201020273）
