广州医药2025，Vol.56Issue(8)：1035-1044,10.DOI:10.20223/j.cnki.1000-8535.2025.08.004
可注射水凝胶药物递送系统在肿瘤治疗中的应用
The application of injectable hydrogels as drug delivery systems in tumor treatment
摘要
Abstract
Tumor treatment remains a prominent area of biomedical research.The researches surrounding the adverse reactions and targeted efficacy of various chemotherapy drugs and other therapeutic drugs have driven the development of various drug carriers.These carriers focus on increasing drug concentration at tumor site,minimizing systemic adverse reactions,and improving treatment outcomes.In the reported delivery systems,injectable hydrogels have become an important carrier for the delivery of chemotherapeutic drugs in vivo due to their minimally invasive characteristics.This review systematically summarized the types and characteristics of injectable hydrogels,and further summarized their drug loading methods.At the same time,the application of injectable hydrogels in the delivery of various drugs for tumor treatment was discussed in depth.This review provides dynamic and prospective reference for the potential challenges and possible solutions of the in situ injectable hydrogels for tumor therapy.Injectable hydrogels as drug delivery systems are with good prospects for tumor treatment.关键词
可注射/水凝胶/药物递送/肿瘤治疗Key words
injectable/hydrogel/drug delivery/tumor treatment引用本文复制引用
董强,赵志虎..可注射水凝胶药物递送系统在肿瘤治疗中的应用[J].广州医药,2025,56(8):1035-1044,10.基金项目
国家自然科学基金青年基金(82302701) （82302701）
天津市卫生健康委科技项目面上基金项目(TJWJ2022MS025)及青年基金项目(TJWJ2022QN051) （TJWJ2022MS025）
天津市科技局项目(22JCQNJC01060,22ZYJDSY00110) （22JCQNJC01060,22ZYJDSY00110）
