广州医药2025，Vol.56Issue(8)：1055-1060,6.DOI:10.20223/j.cnki.1000-8535.2025.08.006
免疫炎症通过激活SOCS6/STAT6通路调控前列腺细胞增殖
SOCS6/STAT6 pathway regulates inflammatory proliferation of prostatic cells
摘要
Abstract
Objective To explore the regulatory role of SOCS6/STAT6 pathway in the inflammatory proliferation of prostate cells.Methods The human prostate cell line RWPE-1 was used to establish an inflammation model.Cells were divided into a control(CON)group and an inflammation-stimulated(INF)group,with the latter subjected to lipopolysaccharide(LPS)treatment to simulate an inflammatory environment.The expression levels of interleukin(IL)-1β、IL-6 and IL-8 were detected by ELISA,and the expression levels of suppressor of cytokine signaling 6(SOCS6),signal transducer and activator oftranscription-6,(STAT6),and phosphorylated STAT6 proteins were detected by Western blot.Results The results showed that after LPS treatment,the expression of SOCS6 protein in RWPE-1 cells significantly decreased,while the expression of phosphorylated STAT6 increased.Conclusions The SOCS6/STAT6 pathway may be involved in regulating the inflammatory proliferation of prostate cells by modulating the phosphorylation level of STAT6 under inflammatory conditions.关键词
SOCS6/STAT6/前列腺增生/炎症/细胞增殖Key words
SOCS6/STAT6/benign prostatic hyperplasia/inflammation/cell proliferation引用本文复制引用
陈锦延,李思宁..免疫炎症通过激活SOCS6/STAT6通路调控前列腺细胞增殖[J].广州医药,2025,56(8):1055-1060,6.基金项目
广东医科大学青年培育基金(GDMUQ2021017) （GDMUQ2021017）
