工业微生物2025，Vol.55Issue(4)：24-27,32,5.DOI:10.3969/j.issn.1001-6678.2025.04.008
杆菌肽的生物合成及代谢工程改造研究进展
Research Progress on Biosynthesis and Metabolic Engineering Modifications of Bacitracin
龚若飞 1徐佳慧 1甘天香 1王志1
作者信息
- 1. 湖北工业大学发酵工程教育部重点实验室,湖北 武汉 430068
- 折叠
摘要
Abstract
Bacitracin is a polypeptide antibiotic synthesized by the non-ribosomal enzymatic system of Bacillus licheniformis or Bacillus subtilis.Because of its wide antibacterial spectrum,low absorption rate and good safety in livestock and poultry,bacitracin is widely used in the livestock and poultry breeding.The paper summarizes the molecular structure,bacteriostatic mechanism and synthesis mechanism of bacitracin,and discusses the research progresses of metabolic engineering transformation technology of bacitracin synthesis,aiming at providing valuable references for the fermentation production of bacitracin.关键词
杆菌肽/地衣芽孢杆菌/代谢工程/微生物发酵Key words
bacitracin/Bacillus licheniformis/metabolic engineering/microbial fermentation引用本文复制引用
龚若飞,徐佳慧,甘天香,王志..杆菌肽的生物合成及代谢工程改造研究进展[J].工业微生物,2025,55(4):24-27,32,5.
