海南医科大学学报2025，Vol.31Issue(17)：1344-1352,9.DOI:10.13210/j.cnki.jhmu.20241010.003
不同促排方案的新鲜胚胎移植周期中子宫内膜厚度与妊娠结局相关性分析
Correlation between endometrial thickness and pregnancy outcome in fresh embryo transfer cycles with different protocols of ovulation promotion
摘要
Abstract
Objective:To investigate the correlation between endometrial thickness(EMT)and pregnancy outcomes under dif-ferent protocols of ovulation promotion and to find the range of EMT for optimal clinical pregnancy and live birth rates.Methods:Clinical data of infertility patients aged<38 years who underwent in vitro fertilization/intracytoplasmic monosperm microinjection(IVF/ICSI)for treatment of infertility at the Reproductive Center of Hainan Provincial Women's and Children's Medical Center from August 2017 to December 2022 were retrospectively analyzed,and a total of 1 844 fresh embryo transfer cycles were includ-ed.The fresh embryo transfer cycles were divided into 708 cycles in the agonist long protocol group(Group A)and 1 136 cycles in the antagonist protocol group(Group B)according to the protocol of ovulation promotion,and Groups A and B were divided into three subgroups according to the EMT on the day of HCG,respectively:EMT<8.0 mm,8.0 mm≤EMT≤12.0 mm,EMT>12.0 mm.Data related to basic indexes and clinical outcomes were collected from each group,and the correlation between EMT and pregnancy outcomes of fresh embryo transfer under different regimens of ovulation promotion was explored by one-way analy-sis,multifactorial logistic regression analysis,smoothed curve fitting and threshold effect analysis.Results:The differences in clin-ical pregnancy rate and live birth rate among different EMT subgroups in Groups A and B were statistically significant(P<0.05),and the differences among miscarriage rate,ectopic pregnancy rate,mean gestational week of delivery of a single fetus,and mean weight of a single birth group were not statistically significant(P>0.05).The results of multifactorial logistic regression analysis showed that the increase in EMT was significantly correlated with the increase in clinical pregnancy rate and live birth rate in Groups A and B(P<0.05).Combining the smoothed curve fit plots of the two groups with the results of the threshold effect analy-sis,it was found that when the EMT was<10.2 mm,the clinical pregnancy rate in the two groups increased significantly with the increase of EMT(a OR=1.36;95%CI=1.11,1.67,P=0.003),(a OR=1.22;95%CI=1.06,1.41,P=0.006);when the EMT≥10.2 mm,the clinical pregnancy rate in both groups changed smoothly with increasing EMT.And the live birth rate in-creased with increasing EMT in both groups.Conclusion:Clinical pregnancy rates in the agonist long protocol group and antago-nist protocol group in fresh embryo transfer cycles increased significantly with the thickening of the EMT,and the clinical pregnan-cy rates leveled off when the EMT reached 10.2 mm.The live birth rate increased with the thickening of the EMT.关键词
辅助生殖技术/新鲜胚胎移植周期/子宫内膜厚度/妊娠结局Key words
Assisted reproductive technology/Fresh embryo transfer cycle/Endometrial thickness/Pregnancy outcome分类
医药卫生引用本文复制引用
吴春娇,吴亚妹,马宁,宋心怡,符宇,伍桂思,潘奕好,卢伟英..不同促排方案的新鲜胚胎移植周期中子宫内膜厚度与妊娠结局相关性分析[J].海南医科大学学报,2025,31(17):1344-1352,9.基金项目
This study was supported by the National Natural Science Foundation of China(82260304) 国家自然科学基金资助项目(82260304) （82260304）
