国际神经病学神经外科学杂志2025，Vol.52Issue(4)：46-52,7.DOI:10.16636/j.cnki.jinn.1673-2642.2025.04.008
沉默信息调节因子1在创伤性颅脑损伤中发挥神经保护作用的研究进展
Research advances in the neuroprotective effect of sirtuin 1 in traumatic brain injury
摘要
Abstract
Patients with traumatic brain injury tend to have high morbidity,mortality,and disability rates,posing a heavy burden on public health,and it is of great importance to explore new treatment methods for traumatic brain injury.The sirtuin family members are crucial regulators of energy homeostasis,among which sirtuin 1(SIRT1)exerts a neuroprotective effect in various nervous system diseases.This article introduces the neuroprotective mechanism of SIRT1 in traumatic brain injury and summarizes the pharmaceutical research on the treatment of traumatic brain injury by targeting SIRT1.关键词
创伤性颅脑损伤/沉默信息调节因子1/神经炎症/细胞凋亡/氧化应激Key words
traumatic brain injury/sirtuin 1/neuroinflammation/cell apoptosis/oxidative stress分类
医药卫生引用本文复制引用
吴济良,张刚利..沉默信息调节因子1在创伤性颅脑损伤中发挥神经保护作用的研究进展[J].国际神经病学神经外科学杂志,2025,52(4):46-52,7.基金项目
山西省自然科学基金面上项目(202203021211060). （202203021211060）
