国际神经病学神经外科学杂志2025，Vol.52Issue(4)：85-96,12.DOI:10.16636/j.cnki.jinn.1673-2642.2025.04.013
帕金森病动物模型的研究进展
Research advances in animal models of Parkinson disease
摘要
Abstract
Parkinson disease(PD)mainly affects the motor functions of the central nervous system,and due to its complex pathogenesis and a lack of effective therapies,it has always been a research hotspot in neuroscience.In recent years,significant progress has been made in the development of animal models for PD.Neurotoxin-induced models can cause dopaminergic neuronal injury and are often used for the screening of neuroprotective drugs,but they fail to fully represent the pathological features of PD.Transgenic models help to identify potential therapeutic targets,but with a lack of significant degeneration of dopaminergic neurons.Composite models can generate a wider range of motor and non-motor symptoms and comprehensively simulate the pathological process of PD.Models induced by α-synuclein can exhibit significant pathological protein aggregation,which closely resembles the typical pathological manifestations of PD.Emerging models can display the pathological features of PD in vitro and facilitate the development of individualized treatment.An increasing number of studies have shown that PD is more likely to be a syndrome,and the research on non-motor symptoms has gained more and more attention.Studies on animal models of non-motor symptoms have the potential to identify biomarkers in the early stage and provide therapies for severe non-motor symptoms.This article reviews the advantages and limitations of various animal models of PD,so as to provide a reference for researchers and help them select appropriate models based on experimental objectives.In addition,this article provides theoretical support for a deeper understanding of the pathogenesis of PD and the development of new therapies.关键词
帕金森病/动物模型/研究进展Key words
Parkinson disease/animal model/research advance分类
医药卫生引用本文复制引用
蒋戴忆,姚舜禹,林兰馨,康徐惠,彭永..帕金森病动物模型的研究进展[J].国际神经病学神经外科学杂志,2025,52(4):85-96,12.基金项目
湖南省卫生健康委员会重点指导课题(C202303076574) （C202303076574）
湖南省中医药管理局重点课题(A2023039) （A2023039）
株洲市科技局课题(2021-009) （2021-009）
湖南中医药高等专科学校附属第一医院优秀科研创新团队(B2021-003) （B2021-003）
2022年湖南中医药大学校院联合基金项目(2022-44). （2022-44）
