郑州大学学报（医学版）2025，Vol.60Issue(5)：727-731,5.DOI:10.13705/j.issn.1671-6825.2025.04.036
类固醇激素反应性慢性淋巴细胞性炎症伴脑桥周围血管强化症5例临床分析
Clinical analysis of 5 cases of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids
摘要
Abstract
Aim:To summarize clinical,imaging and neuropathological features of chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids(CLIPPERS).Methods:Clinical data of 5 CLIPPERS patients from the First Affiliated Hospital of Zhengzhou University from 2016 to 2023 were summarized.Results and Conclusion:The clinical manifestations of the 5 patients were vertigo,ataxia and other symptoms,and the head MRI showed typical pep-per-and-salt-like enhanced lesions,and a large number of T lymphocytes formed a circumferential infiltration around blood vessels were found pathologically,3 cases met the diagnostic criteria both clinically and pathologically.The symptoms and images of the 5 patients were significantly improved after treated by steroid,but 3 patients relapsed after drug withdrawal.CLIPPERS have unique clinical,imaging and neuropathological features.If tumor cannot be ruled out,brain biopsy is con-sidered for the definitive diagnosis.Steroid pulse therapy can improve symptoms effectively,however,premature discontinua-tion of steroids is prone to recurrence,so it requires long-term therapy.关键词
CLIPPERS/类固醇激素冲击治疗/胡椒盐样强化灶/T细胞浸润Key words
CLIPPERS/steroid pulse therapy/pepper-and-salt-like enhanced lesion/T lymphocyte infiltration分类
医药卫生引用本文复制引用
孙桂芳,袁志浩,胡文涛,高远,李新强,白蓉,田德才,卢宏..类固醇激素反应性慢性淋巴细胞性炎症伴脑桥周围血管强化症5例临床分析[J].郑州大学学报（医学版）,2025,60(5):727-731,5.基金项目
国家自然科学基金项目(81501111) （81501111）
河南省教育厅高校重点科研项目(18A320065,23A320062) （18A320065,23A320062）
