昆明医科大学学报2025，Vol.46Issue(8)：78-85,8.DOI:10.12259/j.issn.2095-610X.S20250811
糖尿病患者并发心肌病的危险因素及与血清FOXO1、GDF11、MMP3水平的相关性
Risk Factors of Cardiomyopathy in Patients with Diabetes and Their Correlations with the Levels of Serum FOXO1,GDF11 and MMP3
摘要
Abstract
Objective To explore the risk factors of cardiomyopathy in patients with diabetes and their correlations with the levels of serum fork head box protein O1(FOXO1),growth differentiation factor 11(GDF11),and matrix metalloproteinase-3(MMP3).Methods 200 patients with diabetes complicated with cardiomyopathy and 200 patients with simple diabetes admitted to the People's Hospital of Xinjiang Uygur Autonomous Region from September 2023 to April 2025 were selected to detect serum FOXO1,GDF11 and MMP3 levels,analyze their correlation with cardiac function parameters,screen risk factors through multifactor logistic regression,construct a nomogram model and a receiver operating characteristic(ROC)curve,and evaluate the diagnostic value.Results The duration of diabetes cardiomyopathy group≥10 years,the expression rate of reactive oxygen species(ROS)≥90%,the insulin resistance index and the levels of FOXO1 and MMP3 were significantly higher than those in the simple diabetes group(P<0.05),and the level of GDF11 was lower than that in the simple diabetes group(P<0.05).FOXO1 and MMP3 were positively correlated with E/e'and negatively correlated with LVEF and E/A;GDF11 was negatively correlated with E/e'and positively correlated with LVEF and E/A(P<0.05).The nomogram model showed that the weights of the influencing factors were GDF11,FOXO1,insulin resistance index,MMP3,ROS expression rate,and the course of diabetes.The model calibration was good(χ2=7.336,P=0.719).The combined diagnostic AUC of FOXO1,GDF11,and MMP3 was 0.950,which was better than that of a single indicator(P<0.05).Conclusion GDF11,FOXO1,Insulin resistance index,MMP3,ROS expression rate and the course of diabetes are risk factors for diabetes cardiomyopathy,and the combination of the three is of high diagnostic value.关键词
糖尿病并发心肌病/危险因素/FOXO1/GDF11/MMP3Key words
Diabetes mellitus complicated with cardiomyopathy/Risk factors/FOXO1/GDF1/MMP3分类
医药卫生引用本文复制引用
赵生霞,卢佩佩,陈媛,宋金萍..糖尿病患者并发心肌病的危险因素及与血清FOXO1、GDF11、MMP3水平的相关性[J].昆明医科大学学报,2025,46(8):78-85,8.基金项目
新疆维吾尔自治区自然科学基金项目(2022D01C617) （2022D01C617）
