昆明医科大学学报2025，Vol.46Issue(8)：86-92,7.DOI:10.12259/j.issn.2095-610X.S20250812
12 688名18～60岁女性高危型HPV感染危险因素及基因类型分布分析
Analysis of Risk Factors and Gene Type Distribution of High Risk HPV Infection in 12688 Women Aged 18-60
摘要
Abstract
Objective To discuss the risk factors and genotype distribution of high-risk human papillomavirus(HR-HPV)infection in women aged 18～60 in Liaoning region.Methods A total of 12688 women aged 18～60 from Liaoning Province from June to December 2024 were selected as the research subjects.Logistic regression analysis was used to screen risk factors for HR-HPV infection in women aged 18～60 in the Liaoning region,and the distribution of gene types was statistically analyzed.Results Among 12688 women aged 18～60 in Liaoning region,2992(23.58%)were infected with HR-HPV.Among the 2992 with HR-HPV infection,2804 were infected with single infection and 188 with mixed infection.Among the 2804 single infected individuals,the main genetic types were HPV 16,HPV 52,and HPV 58 respectively.The results of logistic regression analysis showed that divorce or widowhood(OR=3.005,P=0.001),age of first sexual intercourse younger than 18 years old(OR=2.111,P=0.002),number of abortions more than 2 times(OR=1.703,P=0.000),lack of previous HPV vaccination(OR=4.852,P=0.000),smoking history(OR=3.169,P=0.000),cervical and vaginal inflammation(OR=4.741,P=0.002),and syphilis infection(OR=3.726,P=0.000)were independent risk factors for HR-HPV infection in women aged 18～60 in Liaoning region.Conclusion The main genotypes of HR-HPV infection among women aged 18-60 in Liaoning region were HPV 16,HPV 52,and HPV 58.HR-HPV infection was associated with divorce or widowhood,age of first sexual intercourse"<18 years old",number of abortions"≥2 times",lack of previous HPV vaccination,smoking history,cervical and vaginal inflammation,syphilis infection.It is recommended that prevention and control measures for HR-HPV infection among women aged 18-60 years in Liaoning region be formulated and optimized targeting the aforementioned independent risk factors,so as to reduce the HR-HPV infection rate in this population.关键词
女性/高危型人乳头瘤病毒/危险因素/基因类型Key words
Women/High-risk human papillomavirus/Risk factors/Genotype分类
医药卫生引用本文复制引用
兰兰,肖轩..12 688名18～60岁女性高危型HPV感染危险因素及基因类型分布分析[J].昆明医科大学学报,2025,46(8):86-92,7.基金项目
辽宁省卫生厅指导性科研计划课题(BZ20232645) （BZ20232645）
