临床肝胆病杂志2025，Vol.41Issue(8)：1491-1496,6.DOI:10.12449/JCH250803
肝细胞癌系统治疗进展与展望
Advances and prospects of systemic therapy for hepatocellular carcinoma
黄勇 1黄声稀 2刘秀峰1
作者信息
- 1. 东部战区总医院全军肿瘤中心 肿瘤内科,南京 210002
- 2. 东部战区总医院全军肿瘤中心 特诊科,南京 210002
- 折叠
摘要
Abstract
Ground-breaking advances have been made in systemic therapy for hepatocellular carcinoma(HCC),which have significantly improved the clinical prognosis of patients with advanced HCC.This article summarizes the key advances and clinical challenges in systemic therapy for HCC.With the combination of various novel targeted therapy and immunotherapy regimens and the application of dual immunotherapy regimens,there has been an increasing number of clinical treatment options,while there are still key challenges such as optimization of treatment regimens,management of drug resistance,and treatment of special populations.Current studies are exploring precise classification based on multi-omics characteristics and the strategies for novel combined therapies,and in particular,triple-combination regimens have the potential to break through the bottleneck in efficacy.In the future,it is necessary to establish a more individualized and refined whole-course management system and further improve the long-term survival benefits of patients by optimizing immune microenvironment modulation and transforming therapeutic paradigms.Advances in this field will promote the transition from traditional paradigm to precision medicine in the treatment of HCC.关键词
癌,肝细胞/系统治疗/药物疗法,联合Key words
Carcinoma,Hepatocellular/Systemic Therapy/Durg Therapy,Combination引用本文复制引用
黄勇,黄声稀,刘秀峰..肝细胞癌系统治疗进展与展望[J].临床肝胆病杂志,2025,41(8):1491-1496,6.
