器官移植2025，Vol.16Issue(5)：701-709,9.DOI:10.12464/j.issn.1674-7445.2025217
肝移植物缺血-再灌注损伤的防治策略与未来展望
Strategies and future prospects for the prevention and treatment of ischemia-reperfusion injury in liver graft
摘要
Abstract
Ischemia-reperfusion injury(IRI)of the donor liver is inevitable during procurement,preservation and transplantation,directly affecting the outcome of liver transplantation.It is the main cause of early allograft dysfunction and acute/chronic graft rejection after liver transplantation.It is also the main risk factor that affects the use of marginal grafts and exacerbates donor shortage.With the rapid development of biomedical technology,continuous improvements have been made in donor liver preconditioning,preservation perfusion techniques,and pharmacological treatments.Particularly significant progress and breakthroughs have been achieved in the areas of machine perfusion technology,ischaemia-free liver transplantation,anti-oxidation,anti-apoptosis and anti-inflammatory treatments.These advances have significantly reduced or prevented IRI in donor livers,extended the preservation time of donor livers ex vivo,reduced a series of severe complications after liver transplantation,and also significantly increased the utilization rate of marginal donor livers.This article discusses the progress in mechanisms related to liver IRI and liver preservation methods,and explores existing issues,cutting-edge explorations,and future challenges in effective organ preservation and optimization.关键词
肝移植物/肝缺血-再灌注损伤/器官保存/机械灌注/靶向药/早期移植物功能障碍/扩大标准供者/活性氧簇Key words
Liver graft/Liver ischemia-reperfusion injury/Organ preservation/Machine perfusion/Targeted drug/Early allograft dysfunction/Expanded criteria donor/Reactive oxygen species分类
医药卫生引用本文复制引用
李巍,安源,关连越..肝移植物缺血-再灌注损伤的防治策略与未来展望[J].器官移植,2025,16(5):701-709,9.基金项目
国家自然科学基金区域创新发展联合基金重点支持项目(U20A20360) （U20A20360）
吉林省卫生科研人才专项(2022SCZ06) （2022SCZ06）
吉林省科技厅国际科技合作项目(20220402075GH) （20220402075GH）
