器官移植2025，Vol.16Issue(5)：710-717,8.DOI:10.12464/j.issn.1674-7445.2025169
兔抗人胸腺细胞免疫球蛋白诱导治疗在中国心脏死亡器官捐献供肾肾移植受者中的应用
Application of rabbit anti-human thymocyte immunoglobulin induction therapy in kidney transplant recipients with organ donation after cardiac death in China
摘要
Abstract
Objective To evaluate the efficacy and safety of rabbit anti-human thymocyte immuneglobulin(rATG)induction therapy in kidney transplant recipients from donation after cardiac death in China.Methods This was a prospective,multicenter,single-arm and interventional study conducted in China(NCT03099122).Adult patients who underwent kidney transplantation from donation after cardiac death and received rATG induction therapy(cumulative dose of 5 mg/kg)were included.Univariate and multivariate logistic regression analyses were used to identify factors associated with acute rejection(AR),delayed graft function(DGF),graft failure and patient death.The occurrence of adverse events was also analyzed.Results A total of 115 adult patients were enrolled in the study,of whom 107 were evaluable for efficacy.The incidence of biopsy-proven acute rejection(BPAR)and acute rejection(AR)was 2.8%(95%confidence interval 0.6%-8.0%)and 4.7%(95%confidence interval 1.5%-10.6%),respectively.The incidence of delayed graft function(DGF)was 13.1%(95%confidence interval 7.3%-21.0%).Graft and patient survival rates were 97.2%(95%confidence interval 92.0%-99.4%)and 99.1%(95%confidence interval 94.9%-100%),respectively.Multivariate logistic regression analysis showed that donor serum creatinine and recipient panel reactive antibodies were risk factors for DGF(both P<0.05).Common treatment-emergent adverse events(incidence>5%)included anemia(8.7%),infectious pneumonia(8.7%),and urinary tract infection(8.7%).Conclusions Standard-dose rATG induction therapy demonstrates low incidences of BPAR,AR,and DGF,and good safety in kidney transplant recipients from donation after cardiac death in China.关键词
兔抗人胸腺细胞免疫球蛋白/肾移植/诱导治疗/心脏死亡器官捐献/急性排斥反应/移植物功能延迟恢复/不良反应Key words
Rabbit anti-human thymocyte immuneglobulin/Kidney transplantation/Induction therapy/Donation after cardiac death/Acute rejection/Delayed graft function/Adverse reaction分类
医药卫生引用本文复制引用
薛武军,傅耀文,林涛,王建立,王长希,孙启全,明英姿,叶啟发..兔抗人胸腺细胞免疫球蛋白诱导治疗在中国心脏死亡器官捐献供肾肾移植受者中的应用[J].器官移植,2025,16(5):710-717,8.基金项目
国家自然科学基金项目(82370755) （82370755）
