深圳大学学报（理工版）2025，Vol.42Issue(5)：521-528,8.DOI:10.3724/SP.J.1249.2025.05521
美洲大蠊肠道真菌次生代谢产物
Secondary metabolites of intestinal fungi from Periplaneta americana
摘要
Abstract
Intestinal fungi of Periplaneta americana were investigated to screen for their secondary metabolites.The compounds were isolated and purified via solid-state fermentation,Sephadex LH-20,high performance liquid chroma-tography(HPLC)and thin layer chromatography(TLC),and their structures were identified by nuclear magnetic reso-nance(NMR)spectroscopy and mass spectrometry(MS)data.Eight compounds were isolated from the fermentation products of Aspergillus jensenii ZLY01,identified as violaceol II(1),violaceol I(2),5-(3-hydroxy-5-methylphenoxy)-3-methyl-2-(3-methylbut-2-en-1-yl)-phenol(3),brevianamide V(4),brevianamide K(5),brevianamide R(6),emodin(7),and diorcinol(8).From the fermentation products of Aspergillus sydowii ZLY02,nine compounds were isolated:violaceol II(1),violaceol I(2),acremolin(9),hydroxysydonic acid(10),11-dehydrosydonic acid(11),sydonic acid(12),3-hydroxy-4-(5-hydroxy-5-methyl-1-methylenehexyyl)-benzoic acid(13),engyodontiumone I(14),and(7R)-7-O-methylsydonic donic acid(15).Compounds 4‒6 are diketopiperazine alkaloids isolated from Periplaneta americana intestinal fungi A.jensenii for the first time.The present study enriches the diversity of chemical constituents of the secondary metabolites from Periplaneta americana intestinal fungi.关键词
天然产物化学/美洲大蠊/肠道真菌/次生代谢产物/结构鉴定/生物碱Key words
natural product chemistry/Periplaneta americana/intestinal fungi/secondary metabolites/structural identification/alkaloids分类
医药卫生引用本文复制引用
张可鑫,李东芮,罗琴,张天园,程永现,晏永明..美洲大蠊肠道真菌次生代谢产物[J].深圳大学学报（理工版）,2025,42(5):521-528,8.基金项目
National Natural Science Foundation of China(81773606,82322071) （81773606,82322071）
Shenzhen Fundamental Research Program(JCYJ20210324120213038) 国家自然科学基金资助项目(81773606,82322071) （JCYJ20210324120213038）
深圳市基础研究重点资助项目(JCYJ20210324120213038) （JCYJ20210324120213038）
