现代妇产科进展2025，Vol.34Issue(9)：680-684,690,6.DOI:10.13283/j.cnki.xdfckjz.2025.09.004
PAX1、JAM3甲基化对子宫颈高级别上皮内瘤变诊断的meta分析
PAX1 and JAM3 methylation for the diagnosis of cervical high-grade intraepithelial neo-plasia:a meta-analysis
肖金芬 1张旭梅 1刘懿 1丁尚玮 1曾倩 1李芹1
作者信息
- 1. 昆明医科大学附属延安医院,昆明 650051
- 折叠
摘要
Abstract
Objective:To systematically evaluate the overall diagnostic efficacy of PAX1 and JAM3 dual gene methylation in the diagnosis of cervical high-grade squamous intra-epithelial neoplasia(HSIL)and to provide evidence-based evidence for clinical decision-mak-ing.Methods:CNKI,Wanfang,VIP,CBM,Pubmed,Embase,Web of Science,and Cochrane Li-brary were searched to collect the study of PAX1 and JAM3 gene methylation in the diagnosis of HSIL from the establishment of the database to February 2024.According to the inclusion and exclusion criteria,QUADAS-2 was used to evaluate the quality of the literature,and meta-disc1.4 was used to evaluate the diagnostic value of PAX1 and JAM3 dual gene methylation in HSIL.Results:Seven diagnostic tests were included.The results of meta-analysis showed that the com-bined sensitivity of PAX1 and JAM3 for the diagnosis of CIN2+was 0.78(95%CI:0.75～0.80),the pooled specificity was 0.95(95%CI:0.94～0.95),the pooled positive likelihood ratio(PLR)was 14.610(95%CI:10.116～21.099),and the pooled negative likelihood ratio(NLR)was 0.202(95%CI:0.150～0.273).The pooled area under the curve(AUC)was 0.9694 and the pooled diagnostic odds ratio(DOR)was77.36(95%CI:43.06～138.99).The combined sensitivity of CIN3+for the diagnosis of PAX1 and JAM3 was 0.84(95%CI:0.80～0.87),the pooled specificity was 0.87(95%CI:0.86～0.88),the pooled positive like-lihood ratio(PLR)was 5.911(95%CI:4.765～7.333),and the pooled negative likelihood ratio(NLR)was 0.172(95%CI:0.098～0.304).The pooled area under the curve(AUC)was 0.9251 and the pooled diagnostic odds ratio(DOR)was 34.76(95%CI:20.09～60.13).Conclusions:PAX1 and JAM3 dual gene methylation has high sensitivity and specificity in the diagnosis of HSIL,and has high diagnostic efficacy.关键词
子宫颈癌筛查/子宫颈上皮内瘤变/甲基化/Meta分析Key words
Uterine cervical neoplasms/Cervical intraepithelial neoplasia/Methyla-tion/Meta-analysis分类
医药卫生引用本文复制引用
肖金芬,张旭梅,刘懿,丁尚玮,曾倩,李芹..PAX1、JAM3甲基化对子宫颈高级别上皮内瘤变诊断的meta分析[J].现代妇产科进展,2025,34(9):680-684,690,6.
