现代妇产科进展2025，Vol.34Issue(9)：685-690,6.DOI:10.13283/j.cnki.xdfckjz.2025.09.005
基于病因筛查的孕前干预方案对复发性流产患者再次妊娠结局的影响:一项前瞻性队列研究
Effect of etiology-based preconception intervention on pregnancy outcomes in patients with recurrent spontaneous abortion:a prospective cohort study
摘要
Abstract
Objective:To evaluate the efficacy and safety of an etiology-based precon-ception intervention in improving pregnancy outcomes in patients with recurrent spontaneous a-bortion(RSA).Methods:From November 2021 to November 2023,a total of 286 patients with RSA were enrolled.Preconception intervention was administered based on the etiology identified at enrollment.The primary outcome was the first pregnancy outcome after treatment.Demograph-ic and baseline characteristics were compared between the live birth group and the recurrent pregnancy loss group.Pregnancy complications and neonatal outcomes were recorded in the live birth group.The correlation between etiology,intervention strategies,and subsequent pregnancy outcomes was analyzed.Results:All patients in the cohort received preconception intervention,with a live birth rate of 69.76%after treatment.The most common pregnancy complication was gestational diabetes(35.35%).No severe adverse neonatal outcomes were observed.Advanced maternal age,previous miscarriage count,marital status,and antiphospholipid antibody abnor-malities were identified as high-risk factors affecting pregnancy outcomes(P≤0.05).The du-ration of preconception intervention was significantly associated with pregnancy outcomes in RSA patients with autoantibody abnormalities(P=0.034).Conclusions:Etiology-based pre-conception intervention improves pregnancy outcomes and increases the live birth rate in RSA patients,particularly those with autoantibody abnormalities,without increasing maternal or neo-natal complications.This approach is clinically safe and effective.关键词
复发性流产/孕前干预/队列研究Key words
Recurrent spontaneous abortion/Preconception intervention/Cohort study分类
医药卫生引用本文复制引用
周利炆,樊柏林,曾强,刘海意,唐欢,陈佳曦,李宇琪,高鹏,刘玉敏,李舟,涂巍,崔飞鹏..基于病因筛查的孕前干预方案对复发性流产患者再次妊娠结局的影响:一项前瞻性队列研究[J].现代妇产科进展,2025,34(9):685-690,6.基金项目
武汉市卫健委科研项目(No:WX21Q12) （No:WX21Q12）
同济医院横向课题(No:2023162) （No:2023162）
研究生科技创新项目(No:YC202572) （No:YC202572）
