宿州学院学报2025，Vol.40Issue(6)：25-29,5.DOI:10.3969/j.issn.1673-2006.2025.06.005
提出新指标研究密码子对蛋白质相互作用界面的偏好性
Proposing New Measure to Study Codon Preferences for Protein-Protein Interaction Interfaces
卓玛机1
作者信息
- 1. 阿坝师范学院藏汉双语学院,四川 阿坝州,623002
- 折叠
摘要
Abstract
Elucidating protein-protein interactions remains a major challenge in structural bioinformatics,with signi-ficant implications for drug design and protein engineering.While numerous prediction methods based on physico-chemical properties have been developed for protein-protein interaction interfaces,studies investigating the relation-ship between codons and these interfaces remain scarce.To address this gap,a novel metric is first proposed,the In-terface RSCU Rate(IRR),to quantify synonymous codon preference for interface residues.Subsequently,by calcu-lating the Relative Interface Codon Usage(RICU)and MinMax values,the usage patterns of individual codons and codon pairs across the entire dataset are further studied.Statistical analyses revealed"distinct"codons and codon pairs exhibiting marked interface preference,demonstrating that genetic codon usage influences the composition of protein interaction interfaces.关键词
蛋白质相互作用/界面密码子/偏好性指标/界面残基Key words
protein-protein interaction/interface codon/preference measure/interface residue分类
生物科学引用本文复制引用
卓玛机..提出新指标研究密码子对蛋白质相互作用界面的偏好性[J].宿州学院学报,2025,40(6):25-29,5.
