西北师范大学学报（自然科学版）2025，Vol.61Issue(5)：1-3,3.DOI:10.16783/j.cnki.nwnuz.2025.05.001
复杂二倍半萜calidoustene的全合成
Commentary on the first total synthesis of a complex sesterterpenoid calidoustene isolated from aspergillus calidoustus
摘要
Abstract
Sesterterpenoids represent a structurally complex and diverse class of natural products with a wide range of bioactivities.However,their limited natural availability has hindered in-depth studies.Total synthesis offers a viable and effective approach to access these structurally intricate molecules.This account describes the first total synthesis of a complex sesterterpenoid calidoustene isolated from the fungus Aspergillus calidoustus.The synthesis features an elegant retrosynthetic design and employs a modular synthetic strategy.A key step involves the construction of the densely functionalized C-ring via an intramolecular metal-hydride hydrogen atom transfer(MHAT)-initiated radical cyclization.This approach significantly streamlined the synthetic route.The work establishes a solid material foundation for further research into this class of sesterterpenoids.关键词
萜类化合物/二倍半萜/金属氢原子转移/自由基环化Key words
sesterterpenoids/sesterterpenoid/metal-hydride hydrogen atom transfer/radical cyclization分类
化学化工引用本文复制引用
张灵辉,熊文辉,张辅民..复杂二倍半萜calidoustene的全合成[J].西北师范大学学报（自然科学版）,2025,61(5):1-3,3.基金项目
国家自然科学基金资助项目(22278200) （22278200）
