新医学2025，Vol.56Issue(9)：851-857,7.DOI:10.12464/j.issn.0253-9802.2025-0188
视网膜中央静脉阻塞伴黄斑水肿患者视力损伤及恢复的影响因素:一项单中心单臂干预性研究
Influence factors of visual impairment and recovery in patients with central retinal vein occlusion complicated with macular edema:a single-center single-arm interventional study
摘要
Abstract
Objective To explore the influence factors of visual impairment and recovery in patients with central retinal vein occlusion(CRVO)complicated with macular edema(ME).Methods One hundred patients who were initially diagnosed with CRVO-ME and phlegm and blood stasis syndrome based on traditional Chinese medicine in Eye Hospital,China Academy of Chinese Medical Sciences were involved.They were treated with Quji Tongluo Decoction combinied with intravitreal ranibizumab injections.At baseline and 90 days after treatment,optical coherence tomography angiography(OCTA)was used to measure the vascular density(VD)of optic disc(VD in the whole optic disc scanning area,VD inside disc and peripapillary VD optic disc),the thickness of the retinal nerve fiber layer(RNFL),the vertical cup/disc ratio(C/D),the area of the optic disc,the volume of the optic cup,VD of the superficial capillary plexus(SCP)and the deep capillary plexus in the macula,and central macular thickness 0.003),VD inside disc,optic disc(rs=-0.401,P<0.001),peripapillary VD(rs=-0.315,P=0.001),SCP-VD(rs=-0.291,P=0.003),DCP-VD(rs=-0.258,P=0.009),and CMT(rs=0.334,P=0.001).Multivariate linear regression analysis showed that VD within the optic disc(B=-0.045,P<0.001)and CMT(B=0.001,P=0.018)had a significant impact on visual acuity.After treatment,the changes of BCVA(LogMAR)were correlated with the changes of VD in the whole optic disc scanning area(rs=-0.226,P=0.024),VD within the optic disc(rs=-0.284,P=0.004)and CMT(rs=0.241,P=0.016).Multivariate linear regression analysis showed that the changes of VD within the optic disc(B=-0.028,P=0.006)and CMT(B=0.001,P=0.023)had a significant impact on the improvement of visual acuity.Conclusion The blood flow perfusion of the main vessels in the optic disc is of significance for the occurrence and recovery of CRVO.VD within the optic disc could be used as a new biomarker evaluating visual impairment and prognosis.关键词
视网膜中央静脉阻塞/黄斑水肿/痰瘀互结证/生物标志物/雷珠单抗/祛积通络方/血管密度Key words
Central retinal vein occlusion/Macular edema/Phlegm and blood stasis syndrome/Biomarkers/Ranibizumab/Quji Tongluo Decoction/Vascular density引用本文复制引用
李萱,谢立科,罗金花,郝晓凤..视网膜中央静脉阻塞伴黄斑水肿患者视力损伤及恢复的影响因素:一项单中心单臂干预性研究[J].新医学,2025,56(9):851-857,7.基金项目
国家自然科学基金面上项目(82474582) （82474582）
中国中医科学院眼科医院高水平中医医院"青年人才专项"项目"临床青年人才"方向(GSP5-06) （GSP5-06）
中国中医科学院眼科医院高水平中医医院"领军人才"项目(GSP5-83) （GSP5-83）
中国中医科学院眼科医院高水平中医医院揭榜挂帅项目(GSP4-02) （GSP4-02）
