新医学2025，Vol.56Issue(9)：889-895,7.DOI:10.12464/j.issn.0253-9802.2024-0033
标准化蛋白分解率在长腹膜透析龄慢性肾脏病患者中的诊断价值
Diagnostic value of normalized protein catabolic rate in chronic kidney disease patients with long-term peritoneal dialysis
王洋洋 1胡洁萍 2郑玮 2唐杏明1
作者信息
- 1. 东莞东华医院肾病风湿免疫科,广东 东莞 523000||广东医科大学,广东 湛江 524000
- 2. 东莞东华医院肾病风湿免疫科,广东 东莞 523000
- 折叠
摘要
Abstract
Objective To investigate the clinical characteristics and peritoneal function changes in chronic kidney disease(CKD)patients undergoing long-term peritoneal dialysis(PD),and to evaluate the diagnostic utility of normalized protein catabolic rate(nPCR)in assessing dialysis adequacy in this population.Methods CKD patients receiving continuous ambulatory peritoneal dialysis(CAPD)at Dongguan Tungwah Hospital from 2009 to 2022 were selected,and divided into long-term and short-term dialysis groups.The long-term dialysis group was further categorized into high and low peritoneal equilibration test(PET)subgroups according to the average D/Pcr from PET.Intergroup differences were compared.The trend of solute transport was analyzed using the Friedman's test,while Spearman's correlation and receiver operating characteristic(ROC)curve analysis were employed to assess the correlation between nPCR and dialysis adequacy,and the diagnostic performance of nPCR,respectively.Results Among long-term dialysis patients,those in the high PET subgroup exhibited lower levels of serum albumin and nPCR,but higher creatinine clearance index(Ccr)(all P<0.05).The D/Pcr showed a downward trend followed by an upward trend over the first five years of dialysis(all P<0.05).nPCR was positively correlated with Ccr(rs=0.305,P<0.05)and urea clearance index(Kt/V,rs=0.288,P<0.05),and negatively correlated with D/Pcr(rs=-0.417,P<0.001).The area under the ROC curve for nPCR in diagnosing dialysis adequacy was 0.68(P<0.05).Conclusion In CKD patients with long-term peritoneal dialysis,peritoneal function tends to decline initially and then improve.nPCR can serve as a nutritional indicator for evaluating dialysis adequacy.关键词
腹膜透析/腹膜功能/标准化蛋白分解率/透析充分性/透析龄Key words
Peritoneal dialysis/Peritoneal function/Normalized protein catabolic rate/Dialysis adequacy/Dialysis duration引用本文复制引用
王洋洋,胡洁萍,郑玮,唐杏明..标准化蛋白分解率在长腹膜透析龄慢性肾脏病患者中的诊断价值[J].新医学,2025,56(9):889-895,7.
