新医学2025，Vol.56Issue(9)：896-903,8.DOI:10.12464/j.issn.0253-9802.2025-0189
棕色脂肪组织激活与白色脂肪棕化在糖尿病及葡萄糖代谢调控中的研究进展
Research progress on brown adipose tissue activation and white adipose tissue browning in diabetes mellitus and the regulation of glucose metabolism
摘要
Abstract
Diabetes mellitus has become a chronic metabolic disease that seriously threatens global public health.Its severe complications markedly increase mortality and disability,and insulin resistance is the core pathological mechanism.Thus,new therapeutic targets are needed.In recent years,activation of brown adipose tissue(BAT)and browning of white adipose tissue(WAT),owing to their distinct thermogenic function and metabolic regulatory roles,have become focal areas in the research of diabetes treatment.Accordingly,this review systematically summarizes research advances concerning BAT activation and WAT browning in diabetes mellitus and the regulation of glucose metabolism,with emphasis on the mechanisms by which BAT activation and WAT browning improve insulin sensitivity,maintain glucose homeostasis,and enhance energy metabolism,aiming to provide more precise and effective clinical interventions for patients with diabetes mellitus.关键词
棕色脂肪组织/棕化/糖尿病/葡萄糖代谢/胰岛素抵抗Key words
Brown adipose tissue/Browning/Diabetes mellitus/Glucose metabolism/Insulin resistance引用本文复制引用
熊柳,郑婧,张淼..棕色脂肪组织激活与白色脂肪棕化在糖尿病及葡萄糖代谢调控中的研究进展[J].新医学,2025,56(9):896-903,8.基金项目
贵州省科技厅基础项目(黔科合基础-ZK[2022]) （黔科合基础-ZK[2022]）
