无机材料学报2025，Vol.40Issue(8)：871-887,17.DOI:10.15541/jim20250013
无机生物活性材料调控心肌再生的研究进展
Inorganic Bioactive Materials Regulating Myocardial Regeneration
摘要
Abstract
Cardiovascular disease is the leading cause of death worldwide,with myocardial infarction(MI)being a serious threat to human health and life.Current pharmacological and surgical interventions primarily serve as palliative measures,failing to address the root cause of cardiomyocyte death post-MI.Recent advances in regenerative biomedical materials,however,offer promising solutions.Inorganic bioactive materials,capable of interacting with cells and tissues to activate cellular responses and modulate tissue regeneration,have garnered significant attention in regenerative medicine and tissue engineering.Silicate-based biomaterials(e.g.,bioceramics,bioactive glasses),carbon-based nanomaterials,and metal oxides exhibit remarkable potential in promoting myocardial repair and regeneration.This review highlights the latest progress in inorganic bioactive materials for myocardial regeneration and repair,elucidates their material categories and mechanisms of action,and discusses current challenges in clinical translation,while providing insights into future research directions.关键词
无机生物活性材料/心肌再生/金属氧化物/碳基材料/硅酸盐生物材料/综述Key words
inorganic bioactive material/myocardial regeneration/metal oxide/carbon-based material/silicate biomaterial/review分类
化学化工引用本文复制引用
罗晓民,乔志龙,刘颍,杨晨,常江..无机生物活性材料调控心肌再生的研究进展[J].无机材料学报,2025,40(8):871-887,17.基金项目
国家自然科学基金(22278259) （22278259）
国科温州研究院启动项目(WIUCASQD2020013,WIUCASQD2021030)National Natural Science Foundation of China(22278259) （WIUCASQD2020013,WIUCASQD2021030）
Seed Grants from the Wenzhou Institute,University of Chinese Academy of Sciences(WIUCASQD2020013,WIUCASQD2021030) （WIUCASQD2020013,WIUCASQD2021030）
