无机材料学报2025，Vol.40Issue(8)：888-900,13.DOI:10.15541/jim20250007
无机活性材料在类器官研究领域的应用
Application of Inorganic Bioactive Materials in Organoid Research
摘要
Abstract
As an effective in vitro three-dimensional(3D)model,organoids can simulate the structure and function of corresponding tissues/organs,demonstrating broad application prospects in the biomedical field.The construction of organoids relies on the regulation of stem cell behaviors and multicellular interactions.Inorganic bioactive materials possess excellent biocompatibility and bioactivity,showing wide application in the field of biomedical research.Therefore,they can potentially regulate cell behaviors and cell-cell/cell-matrix interactions in the construction of organoids.In this review,the role of inorganic bioactive materials in organoid research was explored,emphasizing their contribution to organoid development and application,and summarizing the critical steps in organoid construction strategies.Subsequently,the biological functions of inorganic bioactive materials,particularly those compatible with key steps in organoid construction,were systematically elucidated,and the key mechanisms by which inorganic bioactive materials promote organoid development and application were emphasized,including their effects on key signaling pathways,regulations of matrix material properties and cellular energy metabolism.In addition,the application of organoids as auxiliary tools to promote the use of inorganic bioactive materials was reviewed.Finally,the strategies for further advancing organoid research by regulating various physical and biochemical clues provided by inorganic bioactive materials were prospected.关键词
类器官/无机活性材料/类器官发育/生物活性离子/综述Key words
organoid/inorganic bioactive material/organoids development/bioactive ion/review分类
化学化工引用本文复制引用
马文平,韩雅卉,吴成铁,吕宏旭..无机活性材料在类器官研究领域的应用[J].无机材料学报,2025,40(8):888-900,13.基金项目
国家重点研发计划(2023YFB3813000) （2023YFB3813000）
江苏省基础研究计划重点项目(BK20243003) （BK20243003）
上海市海外高层次人才计划 （）
国家重点实验室主任基金National Key Research and Development Program of China(2023YFB3813000) （2023YFB3813000）
Natural Science Foundation of Jiangsu Province(BK20243003) （BK20243003）
Shanghai Talent Scholar Program （）
State Key Lab Director Fund （）
