刘昊天 1杨润煌 2张海平 2吕世云 2高勃 2陶丽新 2罗艳侠 2郭秀花3
作者信息
- 1. 100069 北京,首都医科大学公共卫生学院||100069 北京,首都医科大学公共卫生学院环境与衰老北京市重点实验室
- 2. 100069 北京,首都医科大学公共卫生学院
- 3. 100069 北京,首都医科大学公共卫生学院||100069 北京,首都医科大学公共卫生学院环境与衰老北京市重点实验室||首都医科大学健康医疗大数据国家研究院
- 折叠
摘要
Abstract
Background and objective The incidence and mortality rates of lung cancer remain on the rise,creat-ing an urgent need for screening among high-risk populations and early prevention.This study aims to explore the association and interaction between multidimensional lifestyle,socioeconomic status,and the incidence of lung cancer,and to provide scientific evidence for screening high-risk populations and preventing lung cancer.Methods Healthy lifestyle score was con-structed using information on smoking,alcohol consumption,exercise,diet and sleep obtained through a questionnaire survey.Socioeconomic status was evaluated based on information on education,employment,and family income,and genetic test-ing data were used to assess the risk of genetic variation.A proportional hazards assumption test was conducted,and the Cox proportional hazards model was applied to analyze the associations between healthy lifestyle scores,socioeconomic status,and lung cancer,as well as the interactions among various factors,after adjusting for the risk of genetic variation,age,gender,diabetes,hypertension and the living environment score.Results A total of 245,538 samples that entered the cohort from March,2006 to October,2010 were included and followed up until December 31,2022.The participants were divided into the case group(n=1472)and the control group(n=244,066).The analysis results showed that after adjusting for covariates,there was still an association between the healthy lifestyle score,socioeconomic status,and the incidence of lung cancer:com-pared with participants with a high healthy lifestyle score,the risk of lung cancer in participants with medium and low healthy lifestyle scores was significantly increased,with hazard ratios(HR)of 2.12(95%CI:1.86-2.41)and 3.36(95%CI:2.82-3.99)respectively;compared with participants with high socioeconomic status,the risk of lung cancer in participants with medium and low socioeconomic status was significantly increased,with HR of 1.29(95%CI:1.13-1.48)and 1.67(95%CI:1.46-1.90)respectively.Moreover,there were interactions between smoking status and socioeconomic status(Pfor interaction=0.05),as well as the other four lifestyle factors(Pfor interaction=0.02).Conclusion This study identified the association between multidimensional lifestyle factors and socioeconomic status with the incidence of lung cancer,as well as interactions between smoking and so-cioeconomic status and four other lifestyle factors,providing a scientific basis for screening and prevention in high-risk popula-tions for lung cancer.关键词
肺肿瘤/多维生活方式/社会经济地位/Cox比例风险模型Key words
Lung neoplasms/Multidimensional lifestyle/Socioeconomic status/Cox proportional hazards model
