中国肺癌杂志2025，Vol.28Issue(7)：506-512,7.DOI:10.3779/j.issn.1009-3419.2025.101.11
半乳凝素-3在肺癌微环境中的免疫调控和治疗突破
Galectin-3 in the Lung Cancer Microenvironment:Immunomodulation and Therapeutic Breakthroughs
摘要
Abstract
Lung cancer remains one of the most prevalent and deadly malignancies worldwide,with persistently low five-year survival rates.This poor prognosis is primarily attributed to challenges such as difficulties in early diagnosis,high tumor heterogeneity,and strong therapeutic resistance.Although recent advances in targeted therapies and immune checkpoint inhibi-tors have significantly improved the prognosis of some patients,the majority still encounter primary or secondary resistance.Galectin-3,a multifunctional glycan-binding protein,is constitutively expressed in pulmonary tissues.Its expression encompasses bronchial and alveolar epithelial cells,the pulmonary vasculature,and resident immune cells.Galectin-3 plays a central role in lung cancer progression by regulating tumor cell proliferation,immune evasion,and angiogenesis.The complex immunosuppressive mechanisms within the tumor microenvironment not only facilitate tumor growth and metastasis but also partially limit the ef-ficacy of cancer immunotherapies.Overcoming these barriers requires the exploration of novel regulatory targets to break through therapeutic bottlenecks.This review systematically elucidates the mechanisms by which galectin-3 interacts with immune cells(e.g.,T cells,macrophages)in the tumor microenvironment and evaluates its potential as a therapeutic target,including inhibitor devel-opment and combination immunotherapy strategies.The findings aim to provide a theoretical foundation for advancing galectin-3 as a novel therapeutic target in lung cancer and offer new perspectives for overcoming current immunotherapy resistance.关键词
半乳凝素-3/肺肿瘤/肿瘤微环境/免疫细胞/肿瘤细胞Key words
Galectin-3/Lung neoplasms/Tumor microenvironment/Immune cells/Tumor cells引用本文复制引用
朱宏宝,邓炯,王彤..半乳凝素-3在肺癌微环境中的免疫调控和治疗突破[J].中国肺癌杂志,2025,28(7):506-512,7.基金项目
This paper was supported by the grants from National Natural Science Foundation of China(No.82103571),Youth Natural Science Foundation of Shandong Province(No.ZR2021QH295)and Development Plan for Youth Innovation Teams in Colleges and Universities of Shandong Province of China(No.2023KJ249) 本文受国家自然科学基金项目(No.82103571)、山东省青年自然科学基金项目(No.ZR2021QH295)和山东省高等学校青年创新团队发展计划项目(No.2023KJ249)资助 （No.82103571）
