中国肺癌杂志2025，Vol.28Issue(7)：513-520,8.DOI:10.3779/j.issn.1009-3419.2025.106.17
Notch信号通路在小细胞肺癌中作用的研究进展
Research Progress on the Role of Notch Signaling Pathway in Small Cell Lung Cancer
顾飞雪 1赵凯悦 1闫恒硕 1隋东昕2
作者信息
- 1. 250033 济南,山东大学第二临床学院
- 2. 山东大学第二医院呼吸内科
- 折叠
摘要
Abstract
Small cell lung cancer(SCLC),a highly aggressive subtype of lung cancer that originates from pulmo-nary neuroendocrine cells,accounts for 10%to 15%of all lung cancers.It is characterized by a high rate of early metastasis and extremely poor prognosis,often accompanied by challenges such as drug resistance and recurrence.Related researches indi-cates that the Notch signaling pathway plays a crucial role in the occurrence and development of SCLC by regulating processes such as cell proliferation,differentiation,and apoptosis.In SCLC,abnormal Notch signaling may promote tumor malignancy and the occurrence of drug resistance.Additionally,the Notch pathway is involved in the epithelial-mesenchymal transition of SCLC and influences immune escape mechanisms through interactions with the tumor immune microenvironment.This article reviews the molecular mechanisms of Notch signaling in SCLC,including the roles of its receptors and ligands,signal transduction processes,and its role in tumorigenesis.It also discusses the research progress of Notch signaling as a potential therapeutic target and looks forward to future research directions in this field.关键词
肺肿瘤/Notch信号通路/分子机制Key words
Lung neoplasms/Notch signaling pathway/Molecular mechanisms引用本文复制引用
顾飞雪,赵凯悦,闫恒硕,隋东昕..Notch信号通路在小细胞肺癌中作用的研究进展[J].中国肺癌杂志,2025,28(7):513-520,8.
