中国肺癌杂志2025，Vol.28Issue(7)：533-541,9.DOI:10.3779/j.issn.1009-3419.2025.106.20
代谢组学在肺癌研究中的应用及其研究进展
Applications and Advances of Metabolomics in Lung Cancer Research
王道云 1黄志诚 1李博文 1王亚东 1王智娜 2张楠 2魏泽文 3梁乃新 1李单青1
作者信息
- 1. 100730 北京,中国医学科学院,北京协和医学院,北京协和医院胸外科
- 2. 100028 北京,应急总医院呼吸及危重症医学科
- 3. 100081 北京,北京理工大学医学技术学院生物医学工程系
- 折叠
摘要
Abstract
Lung cancer,particularly non-small cell lung cancer(NSCLC),is a leading cause of cancer-related mor-tality worldwide.In recent years,metabolomics has emerged as a key systems biology approach for analyzing small-molecule metabolites in cells,tissues and organisms.It provides new strategies for early diagnosis and metabolic profiling.Additionally,metabolomics plays a crucial role in studying resistance mechanisms in lung cancer.Tumor cell metabolic reprogramming is a key driving factor in the initiation and progression of lung cancer.Metabolomics studies have revealed how lung cancer cells regulate critical pathways such as energy metabolism,lipid metabolism,and amino acid metabolism to adapt to the demands of rapid proliferation and invasive metastasis.This review summarizes the latest advances in metabolomics research in lung cancer,focusing on the characteristics of metabolic reprogramming,the identification of potential metabolic biomarkers,and the pros-pects of metabolomics in early diagnosis and the elucidation of resistance mechanisms in lung cancer.关键词
肺肿瘤/代谢组学/代谢重编程/耐药性Key words
Lung neoplasms/Metabolomics/Metabolic reprogramming/Drug resistance引用本文复制引用
王道云,黄志诚,李博文,王亚东,王智娜,张楠,魏泽文,梁乃新,李单青..代谢组学在肺癌研究中的应用及其研究进展[J].中国肺癌杂志,2025,28(7):533-541,9.
