中国肺癌杂志2025，Vol.28Issue(7)：542-550,9.DOI:10.3779/j.issn.1009-3419.2025.102.28
免疫衰老在老年晚期非小细胞肺癌及其免疫治疗中的研究进展
Research Progress on Immunosenescence in Elderly Patients with Advanced Non-small Cell Lung Cancer and Its Immunotherapy
摘要
Abstract
Lung cancer remains the leading cause of cancer-related incidence and mortality worldwide.Among its histological subtypes,non-small cell lung cancer(NSCLC)accounts for the majority of cases,representing the predominant pathological type.Notably,in the elderly population,NSCLC continues to be a major contributor to cancer-related deaths.With the global ageing population,immunosenescence has emerged as a key factor influencing the occurrence,progression,and the efficacy of immunotherapy of NSCLC.Immunosenescence refers to the age-related decline in immune system function,which manifests as alterations in both the quantity and functionality of immune cells.These include thymic involution,T cell exhaustion,epigenetic modifications,weakened immune responses,and a chronic low-grade inflammatory state.This review comprehensively analyzes the role of immunosenescence in elderly patients with advanced NSCLC and proposes potential therapeutic strategies to intervene in the immunosenescence process.By targeting immunosenescence,these strategies aim to inhibit the progression of NSCLC and improve the effectiveness of immunotherapy.关键词
肺肿瘤/免疫衰老/老年患者/免疫治疗Key words
Lung neoplasms/Immunosenescence/Elderly patients/Immunotherapy引用本文复制引用
王娜,罗娅宁,卢浩宇,崔思远,赵魁,孔凡铭..免疫衰老在老年晚期非小细胞肺癌及其免疫治疗中的研究进展[J].中国肺癌杂志,2025,28(7):542-550,9.基金项目
This paper was supported by the grants from Noncommunicable Chronic Diseases-National Science and Tech-nology Major Project(No.2024ZD0521103),Tianjin Public Health Science and Technology Major Youth Project(No.24ZXGQSY00090)and Open Project of National Clinical Research Center for Chinese Medicine Acupuncture and Moxi-bustion(No.NCRCOP2023007) 本文受癌症、心脑血管、呼吸和代谢性疾病防治研究国家科技重大专项(No.2024ZD0521103)、天津市公共卫生科技重大专项青年项目(No.24ZXGQSY00090)及国家中医针灸临床医学研究中心开放课题(No.NCRCOP2023007)资助 （No.2024ZD0521103）
