EGFR-TKIs治疗失败的肺腺癌子宫内膜转移1例并文献复习
A Case of Endometrial Metastasis in Lung Adenocarcinoma after EGFR-TKIs Treatment Failure and Literature Review
摘要
Abstract
The incidence and mortality rates of lung cancer remain high,making it the leading cause of cancer-related deaths.In women,the predominant histological subtype is lung adenocarcinoma,commonly associated with epidermal growth factor receptor(EGFR)mutations,and EGFR-tyrosine kinase inhibitors(EGFR-TKIs)can significantly improve pa-tient prognosis.Metastasis of primary lung cancer to the endometrium is extremely rare and is often misdiagnosed as a primary reproductive system tumor,and its occurrence indicates poor prognosis.This article reports a case of an advanced lung adeno-carcinoma patient with EGFR mutation,who developed abnormal vaginal bleeding after EGFR-TKIs treatment failure,and biopsy confirmed endometrial metastasis.A review of similar cases is also presented.关键词
肺肿瘤/子宫内膜肿瘤/肿瘤转移/免疫组化/EGFR-TKIsKey words
Lung neoplasms/Endometrial neoplasm/Tumor metastasis/Immunohistochemistry/EGFR-TKIs引用本文复制引用
申芳倩,胡祖玲,杨华,刘璞玉,柏玉举,周建国,马虎..EGFR-TKIs治疗失败的肺腺癌子宫内膜转移1例并文献复习[J].中国肺癌杂志,2025,28(7):551-557,7.基金项目
This paper was supported by the grants from the Zunyi Science and Technology Innovation Talent Team Cultivation Program(No.ZSKRC-2023-01),the Science and Technology Fund Project of the Guizhou Provincial Health Commission(No.WJW-2023-002),the Major Special Project on Science and Technology Innovation 2030 of the Ministry of Science and Technology(No.2023ZD0502105),the Foundation for Outstanding Young Talents in Higher Education Institutions,Guizhou(No.QJJ[2024]333)and the Key Laboratory for Cancer Preven-tion and Treatment of Guizhou Province(No.QKHPT[2025]031) 本文受遵义市科技创新人才团队培养计划(No.ZSKRC-2023-01)、贵州省卫生健康委员会科学技术基金项目(No.WJW-2023-002)、科技部科技创新2030重大专项(No.2023ZD0502105)、贵州省高等学校青年拔尖人才项目(No.黔教技[2024]333号)和贵州省肿瘤防治全省重点实验室(No.QKHPT[2025]031)资助 （No.ZSKRC-2023-01）
